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dc.date.accessioned | 2013-09-30T09:27:31Z | |
dc.date.issued | 2013-01 | |
dc.description.abstract | Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism. | en_GB |
dc.identifier.citation | Nature Genetics, 2013, Vol. 45, Issue 1, pp. 76 - 82 | en_GB |
dc.identifier.doi | 10.1038/ng.2477 | |
dc.identifier.uri | http://hdl.handle.net/10871/13707 | |
dc.language.iso | en | en_GB |
dc.publisher | Nature Publishing Group | en_GB |
dc.relation.url | http://www.ncbi.nlm.nih.gov/pubmed/23202124 | en_GB |
dc.relation.url | http://www.nature.com/ng/journal/v45/n1/full/ng.2477.html | en_GB |
dc.title | New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2013-09-30T09:27:31Z | |
dc.identifier.issn | 1061-4036 | |
dc.identifier.journal | Nature Genetics | en_GB |