Extracellular calreticulin is present in the joints of patients with rheumatoid arthritis and inhibits FasL (CD95L)-mediated apoptosis of T cells
Winyard, Paul G.
Arthritis & Rheumatism
The binding of FasL (CD95L) to its receptor, Fas (CD95), induces apoptosis. Studies have shown that in patients with rheumatoid arthritis (RA), T lymphocytes are resistant to FasL-induced apoptosis in vivo but are susceptible to FasL-induced apoptosis in vitro. Dysfunction in this mechanism may be an important contributor to the pathophysiology of RA. Thus, the present study was undertaken to determine which factors might inhibit FasL-Fas binding in vivo and those that would inhibit apoptosis of T lymphocytes in an in vitro model system.
addresses: Peninsula College of Medicine and Dentistry, and University of Exeter, Exeter, UK.
types: Journal Article; Research Support, Non-U.S. Gov't
The definitive version is available at www3.interscience.wiley.com
Arthritis & Rheumatism, 2010, Vol. 62, Issue 10, pp. 2919 - 2929
Place of publication