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dc.contributor.authorTarr, J.M.
dc.contributor.authorWinyard, Paul G.
dc.contributor.authorRyan, B
dc.contributor.authorHarries, LW
dc.contributor.authorHaigh, Richard
dc.contributor.authorViner, N
dc.contributor.authorEggleton, P
dc.date.accessioned2013-10-21T14:23:18Z
dc.date.issued2010-10
dc.description.abstractThe binding of FasL (CD95L) to its receptor, Fas (CD95), induces apoptosis. Studies have shown that in patients with rheumatoid arthritis (RA), T lymphocytes are resistant to FasL-induced apoptosis in vivo but are susceptible to FasL-induced apoptosis in vitro. Dysfunction in this mechanism may be an important contributor to the pathophysiology of RA. Thus, the present study was undertaken to determine which factors might inhibit FasL-Fas binding in vivo and those that would inhibit apoptosis of T lymphocytes in an in vitro model system.en_GB
dc.identifier.citationArthritis & Rheumatism, 2010, Vol. 62, Issue 10, pp. 2919 - 2929en_GB
dc.identifier.doi10.1002/art.27602
dc.identifier.urihttp://hdl.handle.net/10871/13850
dc.language.isoenen_GB
dc.publisherWiley-Blackwellen_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/20533543en_GB
dc.relation.urlhttp://onlinelibrary.wiley.com/doi/10.1002/art.27602/abstracten_GB
dc.subjectAdulten_GB
dc.subjectAgeden_GB
dc.subjectAged, 80 and overen_GB
dc.subjectApoptosisen_GB
dc.subjectArthritis, Rheumatoiden_GB
dc.subjectCalreticulinen_GB
dc.subjectCase-Control Studiesen_GB
dc.subjectFas Ligand Proteinen_GB
dc.subjectFemaleen_GB
dc.subjectHumansen_GB
dc.subjectJurkat Cellsen_GB
dc.subjectMaleen_GB
dc.subjectMiddle Ageden_GB
dc.subjectSeverity of Illness Indexen_GB
dc.subjectSynovial Fluiden_GB
dc.subjectT-Lymphocytesen_GB
dc.titleExtracellular calreticulin is present in the joints of patients with rheumatoid arthritis and inhibits FasL (CD95L)-mediated apoptosis of T cellsen_GB
dc.typeArticleen_GB
dc.date.available2013-10-21T14:23:18Z
dc.identifier.issn0004-3591
exeter.place-of-publicationUnited States
dc.descriptionaddresses: Peninsula College of Medicine and Dentistry, and University of Exeter, Exeter, UK.en_GB
dc.descriptiontypes: Journal Article; Research Support, Non-U.S. Gov'ten_GB
dc.descriptionThe definitive version is available at www3.interscience.wiley.comen_GB
dc.identifier.journalArthritis & Rheumatismen_GB


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