Towards a gene expression biomarker set for human biological age
Holly, AC; Melzer, D; Pilling, LC; et al.Henley, William E.; Hernandez, Dena; Singleton, AB; Bandinelli, S; Guralnik, Jack; Ferrucci, L; Harries, LW
Date: 1 April 2013
Article
Journal
Aging Cell
Publisher
Wiley-Blackwell
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Abstract
We have previously described a statistical model capable of distinguishing young (age <65 years) from old (age ≥75 years) individuals. Here we studied the performance of a modified model in three populations and determined whether individuals predicted to be biologically younger than their chronological age had biochemical and functional ...
We have previously described a statistical model capable of distinguishing young (age <65 years) from old (age ≥75 years) individuals. Here we studied the performance of a modified model in three populations and determined whether individuals predicted to be biologically younger than their chronological age had biochemical and functional measures consistent with a younger biological age. Those with 'younger' gene expression patterns demonstrated higher muscle strength and serum albumin, and lower interleukin-6 and blood urea concentrations relative to 'biologically older' individuals (odds ratios 2.09, 1.64, 0.74, 0.74; P = 2.4 × 10(-2) , 3.5 × 10(-4) , 1.8 × 10(-2) , 1.5 × 10(-2) , respectively). We conclude that our expression signature of age is robust across three populations and may have utility for estimation of biological age.
Institute of Biomedical & Clinical Science
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