dc.contributor.author | Holly, AC | |
dc.contributor.author | Melzer, D | |
dc.contributor.author | Pilling, LC | |
dc.contributor.author | Henley, William E. | |
dc.contributor.author | Hernandez, Dena | |
dc.contributor.author | Singleton, AB | |
dc.contributor.author | Bandinelli, S | |
dc.contributor.author | Guralnik, Jack | |
dc.contributor.author | Ferrucci, L | |
dc.contributor.author | Harries, LW | |
dc.date.accessioned | 2013-12-03T14:07:33Z | |
dc.date.issued | 2013-04 | |
dc.description.abstract | We have previously described a statistical model capable of distinguishing young (age <65 years) from old (age ≥75 years) individuals. Here we studied the performance of a modified model in three populations and determined whether individuals predicted to be biologically younger than their chronological age had biochemical and functional measures consistent with a younger biological age. Those with 'younger' gene expression patterns demonstrated higher muscle strength and serum albumin, and lower interleukin-6 and blood urea concentrations relative to 'biologically older' individuals (odds ratios 2.09, 1.64, 0.74, 0.74; P = 2.4 × 10(-2) , 3.5 × 10(-4) , 1.8 × 10(-2) , 1.5 × 10(-2) , respectively). We conclude that our expression signature of age is robust across three populations and may have utility for estimation of biological age. | en_GB |
dc.identifier.citation | Vol. 12, Issue 2, pp. 324 - 326 | en_GB |
dc.identifier.doi | 10.1111/acel.12044 | |
dc.identifier.uri | http://hdl.handle.net/10871/14130 | |
dc.language.iso | en | en_GB |
dc.publisher | Wiley-Blackwell | en_GB |
dc.relation.url | http://www.ncbi.nlm.nih.gov/pubmed/23311345 | en_GB |
dc.title | Towards a gene expression biomarker set for human biological age | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2013-12-03T14:07:33Z | |
dc.identifier.issn | 1474-9718 | |
pubs.declined | 2016-02-23T20:15:32.678+0000 | |
pubs.deleted | 2016-02-23T20:15:32.735+0000 | |
exeter.place-of-publication | England | |
dc.description | OnlineOpen Article. This is a copy of an article published in Aging Cell. This journal is available online at: http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1474-9726 | en_GB |
dc.identifier.journal | Aging Cell | en_GB |