Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts
Vimaleswaran, KS; Berry, DJ; Lu, C; et al.Tikkanen, E; Pilz, S; Hiraki, LT; Cooper, JD; Dastani, Z; Li, R; Houston, DK; Wood, Andrew R.; Michaëlsson, K; Vandenput, L; Zgaga, L; Yerges-Armstrong, LM; McCarthy, MI; Dupuis, J; Kaakinen, M; Kleber, ME; Jameson, K; Arden, N; Raitakari, O; Viikari, J; Lohman, KK; Ferrucci, L; Melhus, H; Ingelsson, E; Byberg, L; Lind, L; Lorentzon, M; Salomaa, V; Campbell, H; Dunlop, Malcolm; Mitchell, BD; Herzig, KH; Pouta, A; Hartikainen, AL; Genetic Investigation of Anthropometric Traits-GIANT Consortium; Streeten, EA; Theodoratou, E; Jula, A; Wareham, NJ; Ohlsson, C; Frayling, Timothy M.; Kritchevsky, SB; Spector, TD; Richards, JB; Lehtimäki, T; Ouwehand, WH; Kraft, P; Cooper, Cyrus; März, W; Power, C; Loos, RJ; Wang, TJ; Järvelin, MR; Whittaker, JC; Hingorani, Aroon; Hyppönen, E
Date: 5 February 2013
Article
Journal
PLoS Medicine
Publisher
Public Library of Science
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Abstract
Obesity is associated with vitamin D deficiency, and both are areas of active public health concern. We explored the causality and direction of the relationship between body mass index (BMI) and 25-hydroxyvitamin D [25(OH)D] using genetic markers as instrumental variables (IVs) in bi-directional Mendelian randomization (MR) analysis.
Institute of Biomedical & Clinical Science
Collections of Former Colleges
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