Evidence for a novel functional role of astrocytes in the acute homeostatic response to high-fat diet intake in mice.
© 2014 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
Introduction of a high-fat diet to mice results in a period of voracious feeding, known as hyperphagia, before homeostatic mechanisms prevail to restore energy intake to an isocaloric level. Acute high-fat diet hyperphagia induces astrocyte activation in the rodent hypothalamus, suggesting a potential role of these cells in the homeostatic response to the diet. The objective of this study was to determine physiologic role of astrocytes in the acute homeostatic response to high-fat feeding.
Vanderbilt Digestive Disease Research Center
This is a freely-available open access publication. Please cite the published version which is available via the DOI link in this record.
Molecular Metabolism, 2014, Vol. 4, Issue 1, pp. 58 - 63
DDRC; NIH P30 DK058404
NIH T32 DK007061
Place of publication