Evidence for a novel functional role of astrocytes in the acute homeostatic response to high-fat diet intake in mice.
Buckman, LB; Thompson, MM; Lippert, RN; et al.Blackwell, TS; Yull, FE; Ellacott, KL
Date: 16 October 2014
Journal
Molecular Metabolism
Publisher
Elsevier
Publisher DOI
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Abstract
Introduction of a high-fat diet to mice results in a period of voracious feeding, known as hyperphagia, before homeostatic mechanisms prevail to restore energy intake to an isocaloric level. Acute high-fat diet hyperphagia induces astrocyte activation in the rodent hypothalamus, suggesting a potential role of these cells in the homeostatic ...
Introduction of a high-fat diet to mice results in a period of voracious feeding, known as hyperphagia, before homeostatic mechanisms prevail to restore energy intake to an isocaloric level. Acute high-fat diet hyperphagia induces astrocyte activation in the rodent hypothalamus, suggesting a potential role of these cells in the homeostatic response to the diet. The objective of this study was to determine physiologic role of astrocytes in the acute homeostatic response to high-fat feeding.
Institute of Biomedical & Clinical Science
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