Show simple item record

Evidence for a novel functional role of astrocytes in the acute homeostatic response to high-fat diet intake in mice.

dc.contributor.authorBuckman, LB
dc.contributor.authorThompson, MM
dc.contributor.authorLippert, RN
dc.contributor.authorBlackwell, TS
dc.contributor.authorYull, FE
dc.contributor.authorEllacott, KL
dc.date.accessioned2015-03-06T16:51:51Z
dc.date.issued2014-10-16
dc.description.abstractIntroduction of a high-fat diet to mice results in a period of voracious feeding, known as hyperphagia, before homeostatic mechanisms prevail to restore energy intake to an isocaloric level. Acute high-fat diet hyperphagia induces astrocyte activation in the rodent hypothalamus, suggesting a potential role of these cells in the homeostatic response to the diet. The objective of this study was to determine physiologic role of astrocytes in the acute homeostatic response to high-fat feeding.en_GB
dc.description.sponsorshipVanderbilt Digestive Disease Research Centeren_GB
dc.identifier.citationMolecular Metabolism, 2014, Vol. 4, Issue 1, pp. 58 - 63en_GB
dc.identifier.doi10.1016/j.molmet.2014.10.001
dc.identifier.grantnumberDDRC; NIH P30 DK058404en_GB
dc.identifier.grantnumberNIH T32 DK007061en_GB
dc.identifier.urihttp://hdl.handle.net/10871/16461
dc.language.isoenen_GB
dc.publisherElsevieren_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/25685690en_GB
dc.rights© 2014 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).en_GB
dc.subjectAstrocyteen_GB
dc.subjectCNS, central nervous systemen_GB
dc.subjectFood intakeen_GB
dc.subjectGFAP, glial-fibrillary acidic proteinen_GB
dc.subjectGliaen_GB
dc.subjectHFD, high-fat dieten_GB
dc.subjectHigh-fat dieten_GB
dc.subjectHypothalamusen_GB
dc.subjectMBH, medial basal hypothalamusen_GB
dc.subjectNFκB, nuclear factor kappa Ben_GB
dc.subjectNuclear factor-kappaBen_GB
dc.titleEvidence for a novel functional role of astrocytes in the acute homeostatic response to high-fat diet intake in mice.en_GB
dc.typeArticleen_GB
dc.date.available2015-03-06T16:51:51Z
dc.identifier.issn2212-8778
exeter.place-of-publicationGermany
dc.descriptionThis is a freely-available open access publication. Please cite the published version which is available via the DOI link in this record.en_GB
dc.identifier.journalMolecular Metabolismen_GB


Files in this item

Name:
Buckman et al 2014_Mol Met_Pub ...
Size:
714.3Kb
Format:
PDF
View/Open

This item appears in the following Collection(s)

Show simple item record