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dc.contributor.authorKharche, Sanjay R.
dc.contributor.authorBiktasheva, I. V.
dc.contributor.authorSeemann, Gunnar
dc.contributor.authorZhang, Henggui
dc.contributor.authorBiktashev, V. N.
dc.date.accessioned2015-03-26T10:53:14Z
dc.date.issued2014
dc.description.abstractThe interaction of spiral waves of excitation with atrial anatomy remains unclear. This simulation study isolates the role of atrial anatomical structures on spiral wave spontaneous drift in the human atrium. We implemented realistic and idealised 3D human atria models to investigate the functional impact of anatomical structures on the long-term (~40s) behaviour of spiral waves. The drift of a spiral wave was quantified by tracing its tip trajectory, which was correlated to atrial anatomical features. The interaction of spiral waves with the following idealised geometries was investigated: a) a wedge-like structure with a continuously varying atrial wall thickness; b) a ridge-like structure with a sudden change in atrial wall thickness; c) multiple bridge-like structures consisting of a bridge connected to the atrial wall. Spiral waves drifted from thicker to thinner regions and along ridge-like structures. Break- through patterns caused by pectinate muscles (PM) bridges were also observed, albeit infrequently. Apparent anchoring close to PM-atrial wall junctions was observed. These observations were similar in both the realistic and idealised models. We conclude that spatially altering atrial wall thickness is a significant cause of drift of spiral waves. PM bridges cause break-through patterns and induce transient anchoring of spiral waves.en_GB
dc.description.sponsorshipEngineering and Physical Sciences Research Council (EPSRC)en_GB
dc.description.sponsorshipPRACE HPCen_GB
dc.identifier.citationVolume 2015, Article ID 731386en_GB
dc.identifier.doi10.1155/2015/731386
dc.identifier.grantnumberEP/I029664/1en_GB
dc.identifier.grantnumberEP/I029826/1en_GB
dc.identifier.grantnumberEP/I030158/1en_GB
dc.identifier.grantnumberPRPB09en_GB
dc.identifier.urihttp://hdl.handle.net/10871/16627
dc.language.isoenen_GB
dc.publisherHindawi Publishing Corporationen_GB
dc.relation.urlhttp://www.hindawi.com/journals/bmri/aa/731386/en_GB
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_GB
dc.titleA Computer Simulation Study of Anatomy Induced Drift of Spiral Waves in the Human Atriumen_GB
dc.typeArticleen_GB
dc.date.available2015-03-26T10:53:14Z
dc.identifier.issn2314-6133
exeter.article-number731386
dc.descriptionOpen Access journalen_GB
dc.descriptionCopyright © Sanjay R. Kharche et al.en_GB
dc.identifier.eissn2314-6141
dc.identifier.journalBiomed Research Internationalen_GB


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