Genomics and successful aging: grounds for renewed optimism?
The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences
Oxford University Press
Published by Oxford University Press on behalf of The Gerontological Society of America 2012.
Successful aging depends in part on delaying age-related disease onsets until later in life. Conditions including coronary artery disease, Alzheimer's disease, prostate cancer, and type 2 diabetes are moderately heritable. Genome-wide association studies have identified many risk associated single-nucleotide polymorphisms for these conditions, but much heritability remains unaccounted for. Nevertheless, a great deal is being learned.
Dunhill Medical Trust
U.S. National Institutes of Health
This is a pre-copyedited, author-produced PDF of an article accepted for publication in the Journals of Gerentology following peer review. The version of record is available online at: doi: 10.1093/gerona/gls091.
The Journals of Gerentology, SeriesA, Vol. 67, Issue 5, pp. 511 - 519
Place of publication