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Genomics and successful aging: grounds for renewed optimism?

dc.contributor.authorPilling, LC
dc.contributor.authorHarries, LW
dc.contributor.authorPowell, J
dc.contributor.authorLlewellyn, DJ
dc.contributor.authorFerrucci, L
dc.contributor.authorMelzer, D
dc.date.accessioned2015-06-08T11:33:47Z
dc.date.issued2012-05
dc.description.abstractSuccessful aging depends in part on delaying age-related disease onsets until later in life. Conditions including coronary artery disease, Alzheimer's disease, prostate cancer, and type 2 diabetes are moderately heritable. Genome-wide association studies have identified many risk associated single-nucleotide polymorphisms for these conditions, but much heritability remains unaccounted for. Nevertheless, a great deal is being learned.en_GB
dc.description.sponsorshipDunhill Medical Trusten_GB
dc.description.sponsorshipU.S. National Institutes of Healthen_GB
dc.identifier.citationThe Journals of Gerentology, SeriesA, Vol. 67, Issue 5, pp. 511 - 519en_GB
dc.identifier.doi10.1093/gerona/gls091
dc.identifier.grantnumberR69/0208en_GB
dc.identifier.urihttp://hdl.handle.net/10871/17446
dc.language.isoenen_GB
dc.publisherOxford University Pressen_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/22454374en_GB
dc.rightsPublished by Oxford University Press on behalf of The Gerontological Society of America 2012.en_GB
dc.subjectAgingen_GB
dc.subjectAnimalsen_GB
dc.subjectDiseaseen_GB
dc.subjectGene Expression Regulationen_GB
dc.subjectGenome-Wide Association Studyen_GB
dc.subjectGenomicsen_GB
dc.subjectHumansen_GB
dc.subjectModels, Animalen_GB
dc.subjectPolymorphism, Single Nucleotideen_GB
dc.titleGenomics and successful aging: grounds for renewed optimism?en_GB
dc.typeArticleen_GB
dc.date.available2015-06-08T11:33:47Z
dc.identifier.issn1079-5006
exeter.place-of-publicationUnited States
dc.descriptionThis is a pre-copyedited, author-produced PDF of an article accepted for publication in the Journals of Gerentology following peer review. The version of record is available online at: doi: 10.1093/gerona/gls091.en_GB
dc.identifier.journalThe Journals of Gerontology, Series A: Biological Sciences and Medical Sciencesen_GB


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