The impact of anti-inflammatory cytokines on the pancreatic β-cell
Russell, Mark A.
Morgan, Noel G.
Taylor & Francis
Reason for embargo
Considerable efforts have been invested to understand the mechanisms by which pro-inflammatory cytokines mediate the demise of β-cells in type 1 diabetes but much less attention has been paid to the role of anti-inflammatory cytokines as potential cytoprotective agents in these cells. Despite this, there is increasing evidence that anti-inflammatory molecules such as interleukin (IL)-4, IL-10 and IL-13 can exert a direct influence of β-cell function and viability and that the circulating levels of these cytokines may be reduced in type 1 diabetes. Thus, it seems possible that targeting of anti-inflammatory pathways might offer therapeutic potential in this disease. In the present review, we consider the evidence implicating IL-4, IL-10 and IL-13 as cytoprotective agents in the β-cell and discuss the receptor components and downstream signaling pathways that mediate these effects.
This is an Accepted Manuscript of an article published by Taylor & Francis in Islets on 31 October 2014, available online: http://www.tandfonline.com/10.4161/19382014.2014.950547
Vol. 6 (3), article e950547
Place of publication
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