dc.contributor.author | Russell, Mark A. | |
dc.contributor.author | Morgan, Noel G. | |
dc.date.accessioned | 2015-07-28T12:26:40Z | |
dc.date.issued | 2014-10-31 | |
dc.description.abstract | Considerable efforts have been invested to understand the mechanisms by which pro-inflammatory cytokines mediate the demise of β-cells in type 1 diabetes but much less attention has been paid to the role of anti-inflammatory cytokines as potential cytoprotective agents in these cells. Despite this, there is increasing evidence that anti-inflammatory molecules such as interleukin (IL)-4, IL-10 and IL-13 can exert a direct influence of β-cell function and viability and that the circulating levels of these cytokines may be reduced in type 1 diabetes. Thus, it seems possible that targeting of anti-inflammatory pathways might offer therapeutic potential in this disease. In the present review, we consider the evidence implicating IL-4, IL-10 and IL-13 as cytoprotective agents in the β-cell and discuss the receptor components and downstream signaling pathways that mediate these effects. | en_GB |
dc.identifier.citation | Vol. 6 (3), article e950547 | en_GB |
dc.identifier.doi | 10.4161/19382014.2014.950547 | |
dc.identifier.uri | http://hdl.handle.net/10871/17969 | |
dc.language.iso | en | en_GB |
dc.publisher | Taylor & Francis | en_GB |
dc.relation.url | http://www.ncbi.nlm.nih.gov/pubmed/25322830 | en_GB |
dc.rights.embargoreason | Publisher policy | en_GB |
dc.subject | STAT3 | en_GB |
dc.subject | STAT6 | en_GB |
dc.subject | interleukin-10 | en_GB |
dc.subject | interleukin-13 | en_GB |
dc.subject | interleukin-4 | en_GB |
dc.subject | type 1 diabetes | en_GB |
dc.title | The impact of anti-inflammatory cytokines on the pancreatic β-cell | en_GB |
dc.type | Article | en_GB |
dc.identifier.issn | 1938-2014 | |
exeter.place-of-publication | United States | |
dc.description | This is an Accepted Manuscript of an article published by Taylor & Francis in Islets on 31 October 2014, available online: http://www.tandfonline.com/10.4161/19382014.2014.950547 | en_GB |
dc.identifier.eissn | 1938-2022 | |
dc.identifier.journal | Islets | en_GB |
refterms.dateFOA | 2015-10-31T00:00:00Z | |