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New genetic loci link adipose and insulin biology to body fat distribution

dc.contributor.authorShungin, D
dc.contributor.authorWinkler, TW
dc.contributor.authorCroteau-Chonka, DC
dc.contributor.authorFerreira, T
dc.contributor.authorLocke, AE
dc.contributor.authorMägi, R
dc.contributor.authorStrawbridge, RJ
dc.contributor.authorPers, TH
dc.contributor.authorFischer, Krista
dc.contributor.authorJustice, AE
dc.contributor.authorWorkalemahu, T
dc.contributor.authorWu, JM
dc.contributor.authorBuchkovich, ML
dc.contributor.authorHeard-Costa, NL
dc.contributor.authorRoman, TS
dc.contributor.authorDrong, AW
dc.contributor.authorSong, C
dc.contributor.authorGustafsson, S
dc.contributor.authorDay, Felix R.
dc.contributor.authorEsko, T
dc.contributor.authorFall, T
dc.contributor.authorKutalik, Z
dc.contributor.authorLuan, J
dc.contributor.authorRandall, JC
dc.contributor.authorScherag, A
dc.contributor.authorVedantam, S
dc.contributor.authorWood, Andrew R.
dc.contributor.authorChen, J
dc.contributor.authorFehrmann, R
dc.contributor.authorKarjalainen, J
dc.contributor.authorKahali, B
dc.contributor.authorLiu, CT
dc.contributor.authorSchmidt, EM
dc.contributor.authorAbsher, D
dc.contributor.authorAmin, N
dc.contributor.authorAnderson, D
dc.contributor.authorBeekman, M
dc.contributor.authorBragg-Gresham, JL
dc.contributor.authorBuyske, S
dc.contributor.authorDemirkan, A
dc.contributor.authorEhret, GB
dc.contributor.authorFeitosa, MF
dc.contributor.authorGoel, A
dc.contributor.authorJackson, AU
dc.contributor.authorJohnson, T
dc.contributor.authorKleber, ME
dc.contributor.authorKristiansson, K
dc.contributor.authorMangino, M
dc.contributor.authorMateo Leach, I
dc.contributor.authorMedina-Gomez, C
dc.contributor.authorPalmer, CD
dc.contributor.authorPasko, Dorota
dc.contributor.authorPechlivanis, S
dc.contributor.authorPeters, MJ
dc.contributor.authorProkopenko, I
dc.contributor.authorStančáková, A
dc.contributor.authorJu Sung, Y
dc.contributor.authorTanaka, T
dc.contributor.authorTeumer, A
dc.contributor.authorVan Vliet-Ostaptchouk, JV
dc.contributor.authorYengo, L
dc.contributor.authorZhang, W
dc.contributor.authorAlbrecht, E
dc.contributor.authorÄrnlöv, J
dc.contributor.authorArscott, GM
dc.contributor.authorBandinelli, S
dc.contributor.authorBarrett, A
dc.contributor.authorBellis, C
dc.contributor.authorBennett, AJ
dc.contributor.authorBerne, C
dc.contributor.authorBlüher, M
dc.contributor.authorBöhringer, S
dc.contributor.authorBonnet, F
dc.contributor.authorBöttcher, Y
dc.contributor.authorBruinenberg, M
dc.contributor.authorCarba, DB
dc.contributor.authorCaspersen, IH
dc.contributor.authorClarke, R
dc.contributor.authorDaw, EW
dc.contributor.authorDeelen, J
dc.contributor.authorDeelman, E
dc.contributor.authorDelgado, G
dc.contributor.authorDoney, AS
dc.contributor.authorEklund, N
dc.contributor.authorErdos, MR
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dc.contributor.authorEury, E
dc.contributor.authorFriedrich, N
dc.contributor.authorGarcia, ME
dc.contributor.authorGiedraitis, V
dc.contributor.authorGigante, B
dc.contributor.authorGo, AS
dc.contributor.authorGolay, A
dc.contributor.authorGrallert, H
dc.contributor.authorGrammer, TB
dc.contributor.authorGräßler, J
dc.contributor.authorGrewal, J
dc.contributor.authorGroves, Christopher J.
dc.contributor.authorHaller, T
dc.contributor.authorHallmans, G
dc.contributor.authorHartman, CA
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dc.contributor.authorHunt, SC
dc.contributor.authorIsaacs, A
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dc.contributor.authorJames, AL
dc.contributor.authorJohansson, I
dc.contributor.authorJuliusdottir, T
dc.contributor.authorKalafati, IP
dc.contributor.authorKinnunen, L
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dc.contributor.authorKooner, IK
dc.contributor.authorKratzer, W
dc.contributor.authorLamina, C
dc.contributor.authorLeander, K
dc.contributor.authorLee, NR
dc.contributor.authorLichtner, P
dc.contributor.authorLind, L
dc.contributor.authorLindström, J
dc.contributor.authorLobbens, S
dc.contributor.authorLorentzon, M
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dc.contributor.authorMagnusson, PK
dc.contributor.authorMahajan, A
dc.contributor.authorMcArdle, WL
dc.contributor.authorMenni, C
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dc.contributor.authorMilani, L
dc.contributor.authorMills, R
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dc.contributor.authorMulas, A
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dc.contributor.authorMüller-Nurasyid, M
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dc.contributor.authorNalls, MA
dc.contributor.authorNarisu, N
dc.contributor.authorGlorioso, N
dc.contributor.authorNolte, IM
dc.contributor.authorOlden, M
dc.contributor.authorRayner, NW
dc.contributor.authorRenstrom, F
dc.contributor.authorRied, JS
dc.contributor.authorRobertson, NR
dc.contributor.authorRose, LM
dc.contributor.authorSanna, S
dc.contributor.authorScharnagl, H
dc.contributor.authorScholtens, S
dc.contributor.authorSennblad, B
dc.contributor.authorSeufferlein, T
dc.contributor.authorSitlani, CM
dc.contributor.authorVernon Smith, A
dc.contributor.authorStirrups, K
dc.contributor.authorStringham, HM
dc.contributor.authorSundström, J
dc.contributor.authorSwertz, MA
dc.contributor.authorSwift, AJ
dc.contributor.authorSyvänen, AC
dc.contributor.authorTayo, BO
dc.contributor.authorThorand, B
dc.contributor.authorThorleifsson, G
dc.contributor.authorTomaschitz, A
dc.contributor.authorTroffa, C
dc.contributor.authorvan Oort, FV
dc.contributor.authorVerweij, N
dc.contributor.authorVonk, JM
dc.contributor.authorWaite, LL
dc.contributor.authorWennauer, R
dc.contributor.authorWilsgaard, T
dc.contributor.authorWojczynski, MK
dc.contributor.authorWong, A
dc.contributor.authorZhang, Q
dc.contributor.authorHua Zhao, J
dc.contributor.authorBrennan, EP
dc.contributor.authorChoi, M
dc.contributor.authorEriksson, P
dc.contributor.authorFolkersen, L
dc.contributor.authorFranco-Cereceda, A
dc.contributor.authorGharavi, AG
dc.contributor.authorHedman, ÅK
dc.contributor.authorHivert, MF
dc.contributor.authorHuang, J
dc.contributor.authorKanoni, S
dc.contributor.authorKarpe, F
dc.contributor.authorKeildson, S
dc.contributor.authorKiryluk, K
dc.contributor.authorLiang, L
dc.contributor.authorLifton, RP
dc.contributor.authorMa, B
dc.contributor.authorMcKnight, AJ
dc.contributor.authorMcPherson, R
dc.contributor.authorMetspalu, A
dc.contributor.authorMin, JL
dc.contributor.authorMoffatt, MF
dc.contributor.authorMontgomery, GW
dc.contributor.authorMurabito, JM
dc.contributor.authorNicholson, G
dc.contributor.authorNyholt, DR
dc.contributor.authorOlsson, C
dc.contributor.authorPerry, John R.B.
dc.contributor.authorReinmaa, E
dc.contributor.authorSalem, RM
dc.contributor.authorSandholm, N
dc.contributor.authorSchadt, EE
dc.contributor.authorScott, RA
dc.contributor.authorStolk, L
dc.contributor.authorVallejo, EE
dc.contributor.authorWestra, HJ
dc.contributor.authorZondervan, KT
dc.contributor.authorADIPOGen Consortium
dc.contributor.authorCARDIOGRAMplusC4D Consortium
dc.contributor.authorCKDGen Consortium
dc.contributor.authorGEFOS Consortium
dc.contributor.authorGENIE Consortium
dc.contributor.authorGLGC
dc.contributor.authorICBP
dc.contributor.authorInternational Endogene Consortium
dc.contributor.authorLifeLines Cohort Study
dc.contributor.authorMAGIC Investigators
dc.contributor.authorMuTHER Consortium
dc.contributor.authorPAGE Consortium
dc.contributor.authorReproGen Consortium
dc.contributor.authorAmouyel, P
dc.contributor.authorArveiler, D
dc.contributor.authorBakker, SJ
dc.contributor.authorBeilby, J
dc.contributor.authorBergman, RN
dc.contributor.authorBlangero, J
dc.contributor.authorBrown, MJ
dc.contributor.authorBurnier, M
dc.contributor.authorCampbell, H
dc.contributor.authorChakravarti, A
dc.contributor.authorChines, PS
dc.contributor.authorClaudi-Boehm, S
dc.contributor.authorCollins, FS
dc.contributor.authorCrawford, DC
dc.contributor.authorDanesh, J
dc.contributor.authorde Faire, U
dc.contributor.authorde Geus, Eco
dc.contributor.authorDörr, M
dc.contributor.authorErbel, R
dc.contributor.authorEriksson, Johan G.
dc.contributor.authorFarrall, M
dc.contributor.authorFerrannini, E
dc.contributor.authorFerrières, J
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dc.contributor.authorForrester, T
dc.contributor.authorFranco, OH
dc.contributor.authorGansevoort, RT
dc.contributor.authorGieger, C
dc.contributor.authorGudnason, V
dc.contributor.authorHaiman, CA
dc.contributor.authorHarris, Tamara
dc.contributor.authorHattersley, Andrew T.
dc.contributor.authorHeliövaara, M
dc.contributor.authorHicks, AA
dc.contributor.authorHingorani, Aroon
dc.contributor.authorHoffmann, W
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dc.contributor.authorHumphries, SE
dc.contributor.authorHyppönen, E
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dc.contributor.authorJula, AM
dc.contributor.authorKaprio, J
dc.contributor.authorKee, F
dc.contributor.authorKeinanen-Kiukaanniemi, SM
dc.contributor.authorKooner, JS
dc.contributor.authorKooperberg, C
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dc.contributor.authorKraja, AT
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dc.contributor.authorLakka, TA
dc.contributor.authorLangenberg, C
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dc.contributor.authorLehtimäki, T
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dc.contributor.authorMarette, A
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dc.contributor.authorMcKenzie, CA
dc.contributor.authorMcKnight, B
dc.contributor.authorMusk, AW
dc.contributor.authorMöhlenkamp, S
dc.contributor.authorMorris, AD
dc.contributor.authorNelis, M
dc.contributor.authorOhlsson, C
dc.contributor.authorOldehinkel, AJ
dc.contributor.authorOng, KK
dc.contributor.authorPalmer, LJ
dc.contributor.authorPenninx, BW
dc.contributor.authorPeters, A
dc.contributor.authorPramstaller, PP
dc.contributor.authorRaitakari, OT
dc.contributor.authorRankinen, T
dc.contributor.authorRao, DC
dc.contributor.authorRice, TK
dc.contributor.authorRidker, PM
dc.contributor.authorRitchie, MD
dc.contributor.authorRudan, I
dc.contributor.authorSalomaa, V
dc.contributor.authorSamani, NJ
dc.contributor.authorSaramies, J
dc.contributor.authorSarzynski, MA
dc.contributor.authorSchwarz, PE
dc.contributor.authorShuldiner, AR
dc.contributor.authorStaessen, JA
dc.contributor.authorSteinthorsdottir, V
dc.contributor.authorStolk, RP
dc.contributor.authorStrauch, K
dc.contributor.authorTönjes, A
dc.contributor.authorTremblay, A
dc.contributor.authorTremoli, E
dc.contributor.authorVohl, MC
dc.contributor.authorVölker, U
dc.contributor.authorVollenweider, P
dc.contributor.authorWilson, JF
dc.contributor.authorWitteman, JC
dc.contributor.authorAdair, LS
dc.contributor.authorBochud, M
dc.contributor.authorBoehm, BO
dc.contributor.authorBornstein, SR
dc.contributor.authorBouchard, C
dc.contributor.authorCauchi, S
dc.contributor.authorCaulfield, MJ
dc.contributor.authorChambers, JC
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dc.contributor.authorPalmer, CN
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dc.contributor.authorRauramaa, R
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dc.contributor.authorSlagboom, PE
dc.contributor.authorSnieder, H
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dc.contributor.authorThorsteinsdottir, U
dc.contributor.authorStumvoll, M
dc.contributor.authorTuomilehto, J
dc.contributor.authorUitterlinden, AG
dc.contributor.authorUusitupa, M
dc.contributor.authorvan der Harst, P
dc.contributor.authorVeronesi, G
dc.contributor.authorWalker, M
dc.contributor.authorWareham, NJ
dc.contributor.authorWatkins, H
dc.contributor.authorWichmann, HE
dc.contributor.authorAbecasis, GR
dc.contributor.authorAssimes, TL
dc.contributor.authorBerndt, SI
dc.contributor.authorBoehnke, M
dc.contributor.authorBorecki, IB
dc.contributor.authorDeloukas, P
dc.contributor.authorFranke, L
dc.contributor.authorFrayling, Timothy M.
dc.contributor.authorGroop, Leif
dc.contributor.authorHunter, DJ
dc.contributor.authorKaplan, RC
dc.contributor.authorO'Connell, JR
dc.contributor.authorQi, L
dc.contributor.authorSchlessinger, D
dc.contributor.authorStrachan, DP
dc.contributor.authorStefansson, K
dc.contributor.authorvan Duijn, CM
dc.contributor.authorWiller, CJ
dc.contributor.authorVisscher, PM
dc.contributor.authorYang, J
dc.contributor.authorHirschhorn, JN
dc.contributor.authorZillikens, MC
dc.contributor.authorMcCarthy, MI
dc.contributor.authorSpeliotes, EK
dc.contributor.authorNorth, KE
dc.contributor.authorFox, CS
dc.contributor.authorBarroso, I
dc.contributor.authorFranks, PW
dc.contributor.authorIngelsson, E
dc.contributor.authorHeid, IM
dc.contributor.authorLoos, RJ
dc.contributor.authorCupples, LA
dc.contributor.authorMorris, AP
dc.contributor.authorLindgren, CM
dc.contributor.authorMohlke, KL
dc.date.accessioned2015-09-02T12:44:51Z
dc.date.issued2015-02-11
dc.description.abstractBody fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.en_GB
dc.description.sponsorshipFor funding information see http://www.nature.com/nature/journal/v518/n7538/extref/nature14132-s1.pdfen_GB
dc.identifier.citationVol. 518, pp. 187 - 196en_GB
dc.identifier.doi10.1038/nature14132
dc.identifier.urihttp://hdl.handle.net/10871/18163
dc.language.isoenen_GB
dc.publisherNature Publishing Groupen_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/25673412en_GB
dc.subjectAdipocytesen_GB
dc.subjectAdipogenesisen_GB
dc.subjectAdipose Tissueen_GB
dc.subjectAge Factorsen_GB
dc.subjectBody Fat Distributionen_GB
dc.subjectBody Mass Indexen_GB
dc.subjectContinental Population Groupsen_GB
dc.subjectEpigenesis, Geneticen_GB
dc.subjectEuropeen_GB
dc.subjectFemaleen_GB
dc.subjectGenome, Humanen_GB
dc.subjectGenome-Wide Association Studyen_GB
dc.subjectHumansen_GB
dc.subjectInsulinen_GB
dc.subjectInsulin Resistanceen_GB
dc.subjectMaleen_GB
dc.subjectModels, Biologicalen_GB
dc.subjectNeovascularization, Physiologicen_GB
dc.subjectObesityen_GB
dc.subjectPolymorphism, Single Nucleotideen_GB
dc.subjectQuantitative Trait Locien_GB
dc.subjectSex Characteristicsen_GB
dc.subjectTranscription, Geneticen_GB
dc.subjectWaist-Hip Ratioen_GB
dc.titleNew genetic loci link adipose and insulin biology to body fat distributionen_GB
dc.typeArticleen_GB
dc.date.available2015-09-02T12:44:51Z
dc.identifier.issn0028-0836
exeter.place-of-publicationEngland
dc.identifier.eissn1476-4687
dc.identifier.journalNatureen_GB


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