Drug delivery into microneedle-porated nails from nanoparticle reservoirs.
Chiu, Wing Sin
Belsey, Natalie A.
Begoña Delgado-Charro, M
Guy, Richard H.
Journal of Controlled Release
Author's post-print released with a Creative Commons Attribution Non-Commercial No Derivatives License
Reason for embargo
This study demonstrates the potential of polymeric nanoparticles as drug reservoirs for sustained topical drug delivery into microneedle-treated human nail. Laser scanning confocal microscopy was used to image the delivery of a fluorescent model compound from nanoparticles into the nail. A label-free imaging technique, stimulated Raman scattering microscopy, was applied, in conjunction with two-photon fluorescence imaging, to probe the disposition of nanoparticles and an associated lipophilic 'active' in a microneedle-porated nail. The results provide clear evidence that the nanoparticles function as immobile reservoirs, sequestered on the nail surface and in the microneedle-generated pores, from which the active payload can be released and diffuse laterally into the nail over an extended period of time.
Copyright © 2015. Published by Elsevier B.V.
Author's post-print version. The definitive version is available from the publisher via doi: 10.1016/j.jconrel.2015.10.026
2015 Oct 15. pii: S0168-3659(15)30193-0. doi: 10.1016/j.jconrel.2015.10.026.