Rates of lateral gene transfer in prokaryotes: high but why?
te Beek, TA
van Passel, MW
Trends in Microbiology
© 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Reason for embargo
Lateral gene transfer is of fundamental importance to the evolution of prokaryote genomes and has important practical consequences, as evidenced by the rapid dissemination of antibiotic resistance and virulence determinants. Relatively little effort has so far been devoted to explicitly quantifying the rate at which accessory genes are taken up and lost, but it is possible that the combined rate of lateral gene transfer and gene loss is higher than that of point mutation. What evolutionary forces underlie the rate of lateral gene transfer are not well understood. We here use theory developed to explain the evolution of mutation rates to address this question and explore its consequences for the study of prokaryote evolution.
Netherlands Bioinformatics Centre (NBIC)
European Regional Development Fund
European Social Fund Convergence Programme for Cornwall and the Isles of Scilly
Author version of article. The version of record is available from the publisher via DOI: http://dx.doi.org/10.1016/j.tim.2015.07.006
Copyright © 2015 Elsevier Ltd. All rights reserved.
Vol. 23, pp. 598 - 605
Place of publication