The value of in vitro studies in a case of neonatal diabetes with a novel Kir6.2-W68G mutation.
Hattersley, Andrew T.
Clinical Case Reports
Wiley Open Access
© 2015 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
In infants, especially with novel previously undescribed mutations of the KATP channel causing neonatal diabetes, in vitro studies can be used to both predict the response to sulphonylurea treatment and support a second trial of glibenclamide at higher than standard doses if the expected response is not observed.
This is an open access article available at http://onlinelibrary.wiley.com/doi/10.1002/ccr3.370/full
Vol. 3, Iss. 10, pp. 884 - 887
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