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dc.contributor.authorLaabei, M
dc.contributor.authorUhlemann, AC
dc.contributor.authorLowy, FD
dc.contributor.authorAustin, ED
dc.contributor.authorYokoyama, M
dc.contributor.authorOuadi, K
dc.contributor.authorFeil, E
dc.contributor.authorThorpe, HA
dc.contributor.authorWilliams, B
dc.contributor.authorPerkins, M
dc.contributor.authorPeacock, SJ
dc.contributor.authorClarke, SR
dc.contributor.authorDordel, J
dc.contributor.authorHolden, M
dc.contributor.authorVotintseva, AA
dc.contributor.authorBowden, R
dc.contributor.authorCrook, DW
dc.contributor.authorYoung, BC
dc.contributor.authorWilson, DJ
dc.contributor.authorRecker, M
dc.contributor.authorMassey, RC
dc.date.accessioned2016-03-08T16:42:55Z
dc.date.issued2015
dc.description.abstractBacterial virulence is a multifaceted trait where the interactions between pathogen and host factors affect the severity and outcome of the infection. Toxin secretion is central to the biology of many bacterial pathogens and is widely accepted as playing a crucial role in disease pathology. To understand the relationship between toxicity and bacterial virulence in greater depth, we studied two sequenced collections of the major human pathogen Staphylococcus aureus and found an unexpected inverse correlation between bacterial toxicity and disease severity. By applying a functional genomics approach, we identified several novel toxicity-affecting loci responsible for the wide range in toxic phenotypes observed within these collections. To understand the apparent higher propensity of low toxicity isolates to cause bacteraemia, we performed several functional assays, and our findings suggest that within-host fitness differences between high- and low-toxicity isolates in human serum is a contributing factor. As invasive infections, such as bacteraemia, limit the opportunities for onward transmission, highly toxic strains could gain an additional between-host fitness advantage, potentially contributing to the maintenance of toxicity at the population level. Our results clearly demonstrate how evolutionary trade-offs between toxicity, relative fitness, and transmissibility are critical for understanding the multifaceted nature of bacterial virulence.en_GB
dc.identifier.citationVol. 13, pp. e1002229en_GB
dc.identifier.doi10.1371/journal.pbio.1002229
dc.identifier.otherPBIOLOGY-D-15-01481
dc.identifier.urihttp://hdl.handle.net/10871/20623
dc.language.isoenen_GB
dc.publisherPublic Library of Scienceen_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/26331877en_GB
dc.rightsCopyright: © 2015 Laabei et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_GB
dc.titleEvolutionary trade-offs underlie the multi-faceted virulence of Staphylococcus aureusen_GB
dc.typeArticleen_GB
dc.date.available2016-03-08T16:42:55Z
dc.identifier.issn1544-9173
exeter.place-of-publicationUnited States
dc.descriptionPublished onlineen_GB
dc.descriptionJournal Articleen_GB
dc.descriptionResearch Support, Non-U.S. Gov'ten_GB
dc.identifier.eissn1545-7885
dc.identifier.journalPLoS Biologyen_GB


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