Developing fibre optic Raman probes for applications in clinical spectroscopy
Iping Petterson, IE
Chemical Society Reviews
Royal Society of Chemistry
Reason for embargo
Raman spectroscopy has been shown by various groups over the last two decades to have significant capability in discriminating disease states in bodily fluids, cells and tissues. Recent development in instrumentation, optics and manufacturing approaches has facilitated the design and demonstration of various novel in vivo probes, which have applicability for myriad of applications. This review focusses on key considerations and recommendations for application specific clinical Raman probe design and construction. Raman probes can be utilised as clinical tools able to provide rapid, non-invasive, real-time molecular analysis of disease specific changes in tissues. Clearly the target tissue location, the significance of spectral changes with disease and the possible access routes to the region of interest will vary for each clinical application considered. This review provides insight into design and construction considerations, including suitable probe designs and manufacturing materials compatible with Raman spectroscopy.
The authors wish to thank the National Institute of Health Research (UK) for their support of this work.
This is the author accepted manuscript. The final version is available from the Royal Society of Chemistry via the DOI in this record.
, Vol. 45, pp. 1919 - 1934