The risk of cancer in primary care patients with hypercalcaemia: a cohort study using electronic records.
British Journal of Cancer
Cancer Research UK
This is the final version of the article. Available from Cancer Research UK via the DOI in this record.
BACKGROUND: The risk of cancer with hypercalcaemia in primary care is unknown. METHODS: This was a cohort study using calcium results in patients aged ⩾40 years in a primary care electronic data set. Diagnoses of cancer in the following year were identified. RESULTS: Participants (54 267) had calcium results: 1674 (3%) were ⩾2.6 mmol l(-1). Hypercalcaemia was strongly associated with cancer, especially in males: OR 2.92, 95% CI 2.17-3.93, P=<0.001; positive predictive value (PPV) 11.5%; females: OR 1.86, 95% CI 1.39-2.50, P<0.001: PPV 4.1%. CONCLUSIONS: Hypercalcaemia is strongly associated with cancer in primary care, with men at most risk, despite hypercalcaemia being more common in women.
Vol. 111, pp. 1410 - 1412
Place of publication