dc.contributor.author | Dicken, AJ | |
dc.contributor.author | Evans, JP | |
dc.contributor.author | Rogers, KD | |
dc.contributor.author | Stone, N | |
dc.contributor.author | Greenwood, C | |
dc.contributor.author | Godber, SX | |
dc.contributor.author | Clement, JG | |
dc.contributor.author | Lyburn, ID | |
dc.contributor.author | Martin, RM | |
dc.contributor.author | Zioupos, P | |
dc.date.accessioned | 2016-08-10T10:46:28Z | |
dc.date.issued | 2016-07-01 | |
dc.description.abstract | Osteoporotic fractures present a significant social and economic burden, which is set to rise commensurately with the aging population. Greater understanding of the physicochemical differences between osteoporotic and normal conditions will facilitate the development of diagnostic technologies with increased performance and treatments with increased efficacy. Using coherent X-ray scattering we have evaluated a population of 108 ex vivo human bone samples comprised of non-fracture and fracture groups. Principal component fed linear discriminant analysis was used to develop a classification model to discern each condition resulting in a sensitivity and specificity of 93% and 91%, respectively. Evaluating the coherent X-ray scatter differences from each condition supports the hypothesis that a causal physicochemical change has occurred in the fracture group. This work is a critical step along the path towards developing an in vivo diagnostic tool for fracture risk prediction. | en_GB |
dc.description.sponsorship | This programme of work is funded by an Engineering and Physical Sciences Research Council (grant: EP/K020196/1 Point-of-Care High Accuracy Fracture Risk Prediction). | en_GB |
dc.identifier.citation | Vol. 6, Article no. 29011 | en_GB |
dc.identifier.doi | 10.1038/srep29011 | |
dc.identifier.uri | http://hdl.handle.net/10871/22945 | |
dc.language.iso | en | en_GB |
dc.publisher | Nature Publishing Group | en_GB |
dc.relation.url | http://www.ncbi.nlm.nih.gov/pubmed/27363947 | en_GB |
dc.relation.url | http://www.nature.com/articles/srep29011 | en_GB |
dc.rights | This is the author accepted manuscript. The final version is available from Nature Publishing via the DOI in this record. This work is licensed under a Creative Commons Attribution 4.0 International License. The images
or other third party material in this article are included in the article’s Creative Commons license,
unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license,
users will need to obtain permission from the license holder to reproduce the material. To view a copy of this
license, visit http://creativecommons.org/licenses/by/4.0 | en_GB |
dc.subject | preclinical research | en_GB |
dc.subject | x-rays | en_GB |
dc.title | Classification of fracture and non-fracture groups by analysis of coherent X-ray scatter. | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2016-08-10T10:46:28Z | |
dc.identifier.issn | 2045-2322 | |
exeter.place-of-publication | England | en_GB |
dc.identifier.journal | Scientific Reports | en_GB |