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dc.contributor.authorGreenwood, C
dc.contributor.authorClement, J
dc.contributor.authorDicken, A
dc.contributor.authorEvans, JP
dc.contributor.authorLyburn, I
dc.contributor.authorMartin, RM
dc.contributor.authorRogers, K
dc.contributor.authorStone, N
dc.contributor.authorZioupos, P
dc.date.accessioned2016-11-02T12:02:28Z
dc.date.issued2016-09-10
dc.description.abstractOsteoporosis is a prevalent bone condition, characterised by low bone mass and increased fracture risk. Currently, the gold standard for identifying osteoporosis and increased fracture risk is through quantification of bone mineral density (BMD) using dual energy X-ray absorption (DEXA). However, the risk of osteoporotic fracture is determined collectively by bone mass, architecture and physicochemistry of the mineral composite building blocks. Thus DEXA scans alone inevitably fail to fully discriminate individuals who will suffer a fragility fracture. This study examines trabecular bone at both ultrastructure and microarchitectural levels to provide a detailed material view of bone, and therefore provides a more comprehensive explanation of osteoporotic fracture risk. Physicochemical characterisation obtained through X-ray diffraction and infrared analysis indicated significant differences in apatite crystal chemistry and nanostructure between fracture and non-fracture groups. Further, this study, through considering the potential correlations between the chemical biomarkers and microarchitectural properties of trabecular bone, has investigated the relationship between bone mechanical properties (e.g. fragility) and physicochemical material features.en_GB
dc.description.sponsorshipThis programme of work is funded by an Engineering and Physical Sciences Research Council (grant: EP/K020196/1 Point-of-Care High Accuracy Fracture Risk Prediction).en_GB
dc.identifier.citationVol. 93, pp. 55-63en_GB
dc.identifier.doi10.1016/j.bone.2016.09.006
dc.identifier.otherS8756-3282(16)30252-6
dc.identifier.urihttp://hdl.handle.net/10871/24212
dc.language.isoenen_GB
dc.publisherElsevieren_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/27622884en_GB
dc.rights.embargoreasonPublisher Policyen_GB
dc.rightsThis is the author accepted manuscript. The final version is available from Elsevier via the DOI in this recorden_GB
dc.subjectAgingen_GB
dc.subjectBone qualityen_GB
dc.subjectHydroxyapatiteen_GB
dc.subjectOsteoporosisen_GB
dc.subjectTrabecular boneen_GB
dc.subjectX-ray diffractionen_GB
dc.titleTowards new material biomarkers for fracture risk.en_GB
dc.typeArticleen_GB
dc.identifier.issn8756-3282
exeter.place-of-publicationUnited Statesen_GB
dc.identifier.eissn1873-2763
dc.identifier.journalBoneen_GB


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