Proton-Pump Inhibitors and Fragility Fractures in Vulnerable Older Patients

Zirk-Sadowski, J; Masoli, JA; Strain, WD; et al.Delgado, J; Henley, W; Hamilton, W; Melzer, D; Ble, A
Date: 1 March 2017
Journal
American Journal of Gastroenterology
Publisher
Springer Nature
Publisher DOI
https://doi.org/10.1038/ajg.2016.584
Related links
https://www.ncbi.nlm.nih.gov/pubmed/28270664
Abstract
To the Editor: Proton Pump Inhibitors (PPIs) taken for ≥1 year have been linked to increased fragility fracture (FF) risk, prompting the US FDA to issue a related warning. The oldest old (≥85) and patients with comorbidities may be at greater risk (1); however, little or no evidence has been available in these groups of vulnerable ...
To the Editor: Proton Pump Inhibitors (PPIs) taken for ≥1 year have been linked to increased fragility fracture (FF) risk, prompting the US FDA to issue a related warning. The oldest old (≥85) and patients with comorbidities may be at greater risk (1); however, little or no evidence has been available in these groups of vulnerable people. In this retrospective-matched cohort study with difference-in-difference methods, we investigated the 4-year FF risk in older patients (≥60) and patients with comorbidities. [...]
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Except where otherwise noted, this item's licence is described as Open access. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.