dc.contributor.author | Psatha, M | |
dc.contributor.author | Wu, Z | |
dc.contributor.author | Gammie, F | |
dc.contributor.author | Ratkevicius, A | |
dc.contributor.author | Wackerhage, H | |
dc.contributor.author | Redpath, TW | |
dc.contributor.author | Gilbert, FJ | |
dc.contributor.author | Meakin, JR | |
dc.contributor.author | Aspden, RM | |
dc.date.accessioned | 2017-07-24T10:50:18Z | |
dc.date.issued | 2017-07-20 | |
dc.description.abstract | Background: We previously measured the rate of
regaining muscle strength during rehabilitation of
lower leg muscles in patients following lower leg
casting. Our primary aim in this study was to measure
the rate of gain of strength in healthy individuals
undergoing a similar training regime. Our secondary
aim was to test the ability of MRI to provide a
biomarker for muscle function.
Methods: Men and women were recruited in three age
groups: 20–30, 50–65 and over 70 years. Their
response to resistance training of the right lower leg
twice a week for 8 weeks was monitored using a
dynamometer and MRI of tibialis anterior, soleus and
gastrocnemius muscles at 2 weekly intervals to
measure muscle size (anatomical cross-sectional area
(ACSA)) and quality (T2 relaxation). Forty-four
volunteers completed the study.
Results: Baseline strength declined with age. Training
had no effect in middle-aged females or in elderly men
in dorsiflexion. Other groups significantly increased
both plantarflexion and dorsiflexion strength at rates
up to 5.5 N m week-1 in young females in
plantarflexion and 1.25 N m week-1 in young males in
dorsiflexion. No changes were observed in ACSA or T2
in any age group in any muscle.
Conclusion: Exercise training improves muscle
strength in males at all ages except the elderly in
dorsiflexion. Responses in females were less clear with
variation across age and muscle groups. These results
were not reflected in simple MRI measures that do not,
therefore, provide a good biomarker for muscle
atrophy or the efficacy of rehabilitation | en_GB |
dc.description.sponsorship | This study was supported by an award (Ref: WHMSB_AU118) from
the Translational Medicine Research Collaboration—a consortium made up of
the Universities of Aberdeen, Dundee, Edinburgh and Glasgow, the four
associated NHS Health Boards (Grampian, Tayside, Lothian and Greater
Glasgow & Clyde), Scottish Enterprise and Wyeth. The funder played no part
in the design, execution, analysis or publication of this study. | en_GB |
dc.identifier.citation | Vol. 3, article e000249 | en_GB |
dc.identifier.doi | 10.1136/bmjsem-2017-000249 | |
dc.identifier.uri | http://hdl.handle.net/10871/28590 | |
dc.language.iso | en | en_GB |
dc.publisher | BMJ Publishing Group | en_GB |
dc.rights | Copyright information: © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ | en_GB |
dc.title | Age-related changes in the effects of strength training on lower leg muscles in healthy individuals measured using MRI | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2017-07-24T10:50:18Z | |
dc.identifier.issn | 2055-7647 | |
dc.description | This is the final version of the article. Available from the publisher via the DOI in this record. | en_GB |
dc.identifier.journal | BMJ Open Sport & Exercise Medicine | en_GB |