dc.contributor.author | Jamal, W | |
dc.contributor.author | Das, S | |
dc.contributor.author | Oprescu, I-A | |
dc.contributor.author | Maharatna, K | |
dc.contributor.author | Apicella, F | |
dc.contributor.author | Sicca, F | |
dc.date.accessioned | 2018-01-19T15:53:18Z | |
dc.date.issued | 2014-07-01 | |
dc.description.abstract | OBJECTIVE: The paper investigates the presence of autism using the functional brain connectivity measures derived from electro-encephalogram (EEG) of children during face perception tasks. APPROACH: Phase synchronized patterns from 128-channel EEG signals are obtained for typical children and children with autism spectrum disorder (ASD). The phase synchronized states or synchrostates temporally switch amongst themselves as an underlying process for the completion of a particular cognitive task. We used 12 subjects in each group (ASD and typical) for analyzing their EEG while processing fearful, happy and neutral faces. The minimal and maximally occurring synchrostates for each subject are chosen for extraction of brain connectivity features, which are used for classification between these two groups of subjects. Among different supervised learning techniques, we here explored the discriminant analysis and support vector machine both with polynomial kernels for the classification task. MAIN RESULTS: The leave one out cross-validation of the classification algorithm gives 94.7% accuracy as the best performance with corresponding sensitivity and specificity values as 85.7% and 100% respectively. SIGNIFICANCE: The proposed method gives high classification accuracies and outperforms other contemporary research results. The effectiveness of the proposed method for classification of autistic and typical children suggests the possibility of using it on a larger population to validate it for clinical practice. | en_GB |
dc.description.sponsorship | The work presented in this paper was supported by FP7 EU funded MICHELANGELO project, Grant Agreement #288241. URL: www.michelangelo-project.eu/. | en_GB |
dc.identifier.citation | Vol. 11 (4), article 046019 | en_GB |
dc.identifier.doi | 10.1088/1741-2560/11/4/046019 | |
dc.identifier.uri | http://hdl.handle.net/10871/31111 | |
dc.language.iso | en | en_GB |
dc.publisher | IOP Publishing | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/24981017 | en_GB |
dc.rights | © 2014 IOP Publishing Ltd | en_GB |
dc.subject | Adolescent | en_GB |
dc.subject | Algorithms | en_GB |
dc.subject | Child | en_GB |
dc.subject | Child Development Disorders, Pervasive | en_GB |
dc.subject | Discriminant Analysis | en_GB |
dc.subject | Electroencephalography | en_GB |
dc.subject | Electroencephalography Phase Synchronization | en_GB |
dc.subject | Face | en_GB |
dc.subject | Female | en_GB |
dc.subject | Humans | en_GB |
dc.subject | Male | en_GB |
dc.subject | Neural Pathways | en_GB |
dc.subject | Reproducibility of Results | en_GB |
dc.subject | Support Vector Machine | en_GB |
dc.subject | Visual Perception | en_GB |
dc.title | Classification of autism spectrum disorder using supervised learning of brain connectivity measures extracted from synchrostates | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2018-01-19T15:53:18Z | |
exeter.place-of-publication | England | en_GB |
dc.description | This is the author accepted manuscript. The final version is available from IOP Publishing via the DOI in this record. | en_GB |
dc.identifier.journal | Journal of Neural Engineering | en_GB |