Clinical applications of infrared and raman spectroscopy: state of play and future challenges
The Royal Society of Chemistry
© The Royal Society of Chemistry 2018
Reason for embargo
Under embargo until 27 February 2019 in compliance with publisher policy.
Vibrational spectroscopies, based on infrared absorption and/or Raman scattering provide a detailed fingerprint of a material, based on the chemical content. Diagnostic and prognostic tools based on these technologies have the potential to revolutionise our clinical systems leading to improved patient outcome, more efficient public services and significant economic savings. However, despite these strong drivers, there are many fundamental scientific and technological challenges which have limited the implementation of this technology in the clinical arena, although recent years have seen significant progress in addressing these challenges. This review examines (i) the state of the art of clinical applications of infrared absorption and Raman spectroscopy, and (ii) the outstanding challenges, and progress towards translation, highlighting specific examples in the areas of in vivo, ex vivo and in vitro applications. In addition, the requirements of instrumentation suitable for use in the clinic, strategies for pre-processing and statistical analysis in clinical spectroscopy and data sharing protocols, will be discussed. Emerging consensus recommendations are presented, and the future perspectives of the field are assessed, particularly in the context of national and international collaborative research initiatives, such as the UK EPSRC Clinical Infrared and Raman Spectroscopy Network, the EU COST Action Raman4Clinics, and the International Society for Clinical Spectroscopy.
The authors acknowledge the support of the Clinical Infrared and Raman Spectroscopy for Medical Diagnosis Network, EPSRC grant number EP/L012952/1.
This is the author accepted manuscript. The final version is available from the Royal Society of Chemistry via the DOI in this record.
Vol. 143, pp. 1735-1757