New routes to the functionalization patterning and manufacture of graphene-based materials for biomedical applications
De Sanctis, A
© 2018 The Author(s) Published by the Royal Society. All rights reserved.
Graphene-based materials are being widely explored for a range of biomedical applications, from targeted drug delivery to biosensing, bioimaging and use for antibacterial treatments, to name but a few. In many such applications it is not graphene itself that is used as the active agent, but one of its chemically-functionalised forms. The type of chemical species used for functionalisation will play a key role in determining the utility of any graphene-based device in any particular biomedical application, since this determines to a large part its physical, chemical, electrical and optical interactions. However, other factors will also be important in determining the eventual uptake of graphene-based biomedical technologies, in particular the ease and cost of manufacture of proposed device and system designs. In this work we describe three novel routes for the chemical functionalisation of graphene using oxygen, iron chloride and fluorine. We also introduce novel in-situ methods for controlling and patterning such functionalisation on the micro- and nano-scales. Our approaches are readily transferable to large-scale manufacturing, potentially paving the way for the eventual cost-effective production of functionalised graphene-based materials, devices and systems for a range of important biomedical applications.
AA, VKN, MFC and CDW acknowledge funding via the EU FP7 project CareRAMM (grant no. 309980). SR and MFC. acknowledge financial support from the Engineering and Physical Sciences Research Council (grant nos. EP/J000396/1, EP/K017160/1, EP/K010050/1, EP/G036101/1, EP/M001024/1, and EP/M002438/1).
This is the author accepted manuscript. The final version is available from Royal Society via the DOI in this record.
Vol. 8 (3). Published online 20 April 2018.