dc.contributor.author | Müller, M | |
dc.contributor.author | Schindler, K | |
dc.contributor.author | Goodfellow, M | |
dc.contributor.author | Pollo, C | |
dc.contributor.author | Rummel, C | |
dc.contributor.author | Steimer, A | |
dc.date.accessioned | 2018-05-22T09:29:43Z | |
dc.date.issued | 2018-05-18 | |
dc.description.abstract | BACKGROUND: Quantitative analysis of intracranial EEG is a promising tool to assist clinicians in the planning of resective brain surgery in patients suffering from pharmacoresistant epilepsies. Quantifying the accuracy of such tools, however, is nontrivial as a ground truth to verify predictions about hypothetical resections is missing. NEW METHOD: As one possibility to address this, we use customized hypotheses tests to examine the agreement of the methods on a common set of patients. One method uses machine learning techniques to enable the predictive modeling of EEG time series. The other estimates nonlinear interrelation between EEG channels. Both methods were independently shown to distinguish patients with excellent post-surgical outcome (Engel class I) from those without improvement (Engel class IV) when assessing the electrodes associated with the tissue that was actually resected during brain surgery. Using the AND and OR conjunction of both methods we evaluate the performance gain that can be expected when combining them. RESULTS: Both methods' assessments correlate strongly positively with the similarity between a hypothetical resection and the corresponding actual resection in class I patients. Moreover, the Spearman rank correlation between the methods' patient rankings is significantly positive. COMPARISON WITH EXISTING METHOD(S): To our best knowledge, this is the first study comparing surgery target assessments from fundamentally differing techniques. CONCLUSIONS: Although conceptually completely independent, there is a relation between the predictions obtained from both methods. Their broad consensus supports their application in clinical practice to provide physicians additional information in the process of presurgical evaluation. | en_GB |
dc.description.sponsorship | This work was supported by the Swiss National Science Foundation (SNF) (Project No: SNF 32003B
155950). M.G. gratefully acknowledges the financial support of the EPSRC via grant EP/N014391/1. The contribution of M.G. was generously supported by a Wellcome Trust Institutional Strategic Support Award (WT105618MA). | en_GB |
dc.identifier.citation | Published online 18 May 2018 | en_GB |
dc.identifier.doi | 10.1016/j.jneumeth.2018.04.021 | |
dc.identifier.uri | http://hdl.handle.net/10871/32956 | |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/29753683 | en_GB |
dc.rights | © 2018 The Authors. Published by Elsevier B.V. Open Access funded by Engineering and Physical Sciences Research Council. Under a Creative Commons license: https://creativecommons.org/licenses/by/4.0/ | en_GB |
dc.subject | Epilepsy | en_GB |
dc.subject | Functional network | en_GB |
dc.subject | Method validation | en_GB |
dc.subject | Predictive modeling | en_GB |
dc.subject | Quantitative EEG | en_GB |
dc.subject | Resective surgery | en_GB |
dc.title | Evaluating resective surgery targets in epilepsy patients: a comparison of quantitative EEG methods. | en_GB |
dc.type | Article | en_GB |
dc.identifier.issn | 0165-0270 | |
exeter.place-of-publication | Netherlands | en_GB |
dc.description | This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record. | en_GB |
dc.identifier.journal | Journal of Neuroscience Methods | en_GB |