dc.contributor.author | Tabish, TA | |
dc.contributor.author | Scotton, C | |
dc.contributor.author | Ferguson, D | |
dc.contributor.author | Liangxu, L | |
dc.contributor.author | Veen, A | |
dc.contributor.author | Lowry, S | |
dc.contributor.author | Ali, M | |
dc.contributor.author | Jabeen, F | |
dc.contributor.author | Ali, M | |
dc.contributor.author | Winyard, P | |
dc.contributor.author | Zhang, S | |
dc.date.accessioned | 2018-06-29T14:36:24Z | |
dc.date.issued | 2018-08-20 | |
dc.description.abstract | Aim: Achieving reliably high production of reactive oxygen species (ROS) in photodynamic therapy (PDT) remains challenging. Graphene quantum dots (GQD) hold great promise for PDT. However, the photochemical processes leading to GQD-derived ROS generation have not yet been fully elucidated. Materials & methods: Physicochemical characteristics of GQDs were comprehensively investigated, including electron paramagnetic resonance analysis of singlet oxygen production. Dark toxicity was assessed in vitro and in vivo. Results: GQDs demonstrated excellent photo-luminescent features, corrosion resistance, high water solubility, high photo/pH-stability, in vitro and in vivo biocompatibility and very efficient singlet
oxygen/ROS generation. Conclusion: The enhanced ROS generation, combined with good biocompatibility and minimal toxicity in vitro and in vivo support the potential of GQDs for future PDT application. | en_GB |
dc.description.sponsorship | This work was supported by the EPSRC Centre for Doctoral Training in Metamaterials, XM2 (grant number EP/L015331/1) | en_GB |
dc.identifier.citation | Published online 20 August 2018 | en_GB |
dc.identifier.doi | 10.2217/nnm-2018-0018 | |
dc.identifier.uri | http://hdl.handle.net/10871/33332 | |
dc.language.iso | en | en_GB |
dc.publisher | Future Medicine | en_GB |
dc.rights | © 2018 Tanveer A Tabish. Open access. This work is licensed under the Creative Commons Attribution 4.0 License. To view a copy of this license, visit
http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | graphene quantum dots | en_GB |
dc.subject | singlet oxygen | en_GB |
dc.subject | reactive oxygen species | en_GB |
dc.subject | photostability | en_GB |
dc.subject | biocompatability | en_GB |
dc.subject | toxicity | en_GB |
dc.subject | corrosion resistance | en_GB |
dc.subject | photodynamic therapy | en_GB |
dc.title | Biocompatibility and toxicity of graphene quantum dots for potential application in photodynamic therapy | en_GB |
dc.type | Article | en_GB |
dc.identifier.issn | 1743-5889 | |
dc.description | This is the author accepted manuscript. The final version is available from Future Medicine via the DOI in this record | en_GB |
dc.identifier.journal | Nanomedicine | en_GB |