Enhanced deep detection of Raman scattered light by wavefront shaping

Paniagua-Diaz, AM; Ghita, A; Vettenburg, T; et al.Stone, N; Bertolotti, J
Date: 10 December 2018
Journal
Optics Express
Publisher
Optical Society of America (OSA)
Publisher DOI
https://doi.org/10.1364/OE.26.033565
Related links
http://hdl.handle.net/10871/34990
Abstract
Light scattering limits the penetration depth of non-invasive Raman spectroscopy in biological media. While safe levels of irradiation may be adequate to analyze superficial tissue, scattering of the pump beam reduces the Raman signal to undetectable levels deeper within the tissue. Here we demonstrate how wavefront shaping techniques ...
Light scattering limits the penetration depth of non-invasive Raman spectroscopy in biological media. While safe levels of irradiation may be adequate to analyze superficial tissue, scattering of the pump beam reduces the Raman signal to undetectable levels deeper within the tissue. Here we demonstrate how wavefront shaping techniques can significantly increase the Raman signal at depth, while keeping the total irradiance constant, thus increasing the amount of Raman signal available for detection.
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Physics and Astronomy

Faculty of Environment, Science and Economy

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Journal © 2018. Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI.
Except where otherwise noted, this item's licence is described as Journal © 2018. Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI.