A Burkholderia pseudomallei Toxin Inhibits Helicase Activity of Translation Factor eIF4A
Cruz, A; Hautbergue, GM; Artymiuk, PJ; et al.Baker, PJ; Bokori-Brown, M; Chang, C-T; Dickman, MJ; Essex-Lopresti, A; Harding, SV; Mahadi, NM; Marshall, LE; Mobbs, GW; Mohamed, R; Nathan, S; Ngugi, SA; Ong, C; Ooi, WF; Partridge, LJ; Phillips, HL; Raih, F; Ruzhenikov, S; Sarkar-Tyson, M; Sedelnikova, SE; Smither, SJ; Tan, P; Titball, RW; Wilson, SA; Rice, DW
Date: 11 November 2011
Journal
Science
Publisher
American Association for the Advancement of Science
Publisher DOI
Abstract
The structure of BPSL1549, a protein of unknown function from Burkholderia pseudomallei, reveals a similarity to Escherichia coli cytotoxic necrotizing factor 1. We found that BPSL1549 acted as a potent cytotoxin against eukaryotic cells and was lethal when administered to mice. Expression levels of bpsl1549 correlate with conditions ...
The structure of BPSL1549, a protein of unknown function from Burkholderia pseudomallei, reveals a similarity to Escherichia coli cytotoxic necrotizing factor 1. We found that BPSL1549 acted as a potent cytotoxin against eukaryotic cells and was lethal when administered to mice. Expression levels of bpsl1549 correlate with conditions expected to promote or suppress pathogenicity. BPSL1549 promotes deamidation of glutamine-339 of the translation initiation factor eIF4A, abolishing its helicase activity and inhibiting translation. We propose to name BPSL1549 Burkholderia lethal factor 1.
Biosciences
College of Life and Environmental Sciences
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