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A Burkholderia pseudomallei Toxin Inhibits Helicase Activity of Translation Factor eIF4A

dc.contributor.authorCruz, A
dc.contributor.authorHautbergue, GM
dc.contributor.authorArtymiuk, PJ
dc.contributor.authorBaker, PJ
dc.contributor.authorBokori-Brown, M
dc.contributor.authorChang, C-T
dc.contributor.authorDickman, MJ
dc.contributor.authorEssex-Lopresti, A
dc.contributor.authorHarding, SV
dc.contributor.authorMahadi, NM
dc.contributor.authorMarshall, LE
dc.contributor.authorMobbs, GW
dc.contributor.authorMohamed, R
dc.contributor.authorNathan, S
dc.contributor.authorNgugi, SA
dc.contributor.authorOng, C
dc.contributor.authorOoi, WF
dc.contributor.authorPartridge, LJ
dc.contributor.authorPhillips, HL
dc.contributor.authorRaih, F
dc.contributor.authorRuzhenikov, S
dc.contributor.authorSarkar-Tyson, M
dc.contributor.authorSedelnikova, SE
dc.contributor.authorSmither, SJ
dc.contributor.authorTan, P
dc.contributor.authorTitball, RW
dc.contributor.authorWilson, SA
dc.contributor.authorRice, DW
dc.date.accessioned2019-02-26T15:10:15Z
dc.date.issued2011-11-11
dc.description.abstractThe structure of BPSL1549, a protein of unknown function from Burkholderia pseudomallei, reveals a similarity to Escherichia coli cytotoxic necrotizing factor 1. We found that BPSL1549 acted as a potent cytotoxin against eukaryotic cells and was lethal when administered to mice. Expression levels of bpsl1549 correlate with conditions expected to promote or suppress pathogenicity. BPSL1549 promotes deamidation of glutamine-339 of the translation initiation factor eIF4A, abolishing its helicase activity and inhibiting translation. We propose to name BPSL1549 Burkholderia lethal factor 1.en_GB
dc.identifier.citationVol. 334 (6057), pp. 821-824en_GB
dc.identifier.doihttps://doi.org/10.1126/science.1211915
dc.identifier.urihttp://hdl.handle.net/10871/36076
dc.language.isoenen_GB
dc.publisherAmerican Association for the Advancement of Scienceen_GB
dc.rightsCopyright © 2011, American Association for the Advancement of Science.en_GB
dc.titleA Burkholderia pseudomallei Toxin Inhibits Helicase Activity of Translation Factor eIF4Aen_GB
dc.typeArticleen_GB
dc.date.available2019-02-26T15:10:15Z
dc.identifier.issn0036-8075
dc.descriptionThis is the author accepted manuscript. The final version is available from American Association for the Advancement of Science via the DOI in this record.en_GB
dc.identifier.journalScienceen_GB
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserveden_GB
dcterms.dateAccepted2011-09-23
rioxxterms.versionAMen_GB
rioxxterms.licenseref.startdate2011-09-23
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2019-02-26T15:07:50Z
refterms.versionFCDAM
refterms.dateFOA2019-02-26T15:10:20Z
refterms.panelAen_GB


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