Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates.
dc.contributor.author | Dashti, HS | |
dc.contributor.author | Jones, SE | |
dc.contributor.author | Wood, AR | |
dc.contributor.author | Lane, JM | |
dc.contributor.author | van Hees, VT | |
dc.contributor.author | Wang, H | |
dc.contributor.author | Rhodes, JA | |
dc.contributor.author | Song, Y | |
dc.contributor.author | Patel, K | |
dc.contributor.author | Anderson, SG | |
dc.contributor.author | Beaumont, RN | |
dc.contributor.author | Bechtold, DA | |
dc.contributor.author | Bowden, J | |
dc.contributor.author | Cade, BE | |
dc.contributor.author | Garaulet, M | |
dc.contributor.author | Kyle, SD | |
dc.contributor.author | Little, MA | |
dc.contributor.author | Loudon, AS | |
dc.contributor.author | Luik, AI | |
dc.contributor.author | Scheer, FAJL | |
dc.contributor.author | Spiegelhalder, K | |
dc.contributor.author | Tyrrell, J | |
dc.contributor.author | Gottlieb, DJ | |
dc.contributor.author | Tiemeier, H | |
dc.contributor.author | Ray, DW | |
dc.contributor.author | Purcell, SM | |
dc.contributor.author | Frayling, TM | |
dc.contributor.author | Redline, S | |
dc.contributor.author | Lawlor, DA | |
dc.contributor.author | Rutter, MK | |
dc.contributor.author | Weedon, MN | |
dc.contributor.author | Saxena, R | |
dc.date.accessioned | 2019-03-15T09:33:39Z | |
dc.date.issued | 2019-03-07 | |
dc.description.abstract | Sleep is an essential state of decreased activity and alertness but molecular factors regulating sleep duration remain unknown. Through genome-wide association analysis in 446,118 adults of European ancestry from the UK Biobank, we identify 78 loci for self-reported habitual sleep duration (p < 5 × 10-8; 43 loci at p < 6 × 10-9). Replication is observed for PAX8, VRK2, and FBXL12/UBL5/PIN1 loci in the CHARGE study (n = 47,180; p < 6.3 × 10-4), and 55 signals show sign-concordant effects. The 78 loci further associate with accelerometer-derived sleep duration, daytime inactivity, sleep efficiency and number of sleep bouts in secondary analysis (n = 85,499). Loci are enriched for pathways including striatum and subpallium development, mechanosensory response, dopamine binding, synaptic neurotransmission and plasticity, among others. Genetic correlation indicates shared links with anthropometric, cognitive, metabolic, and psychiatric traits and two-sample Mendelian randomization highlights a bidirectional causal link with schizophrenia. This work provides insights into the genetic basis for inter-individual variation in sleep duration implicating multiple biological pathways. | en_GB |
dc.description.sponsorship | Thoracic Society Foundation | en_GB |
dc.description.sponsorship | NIH/ NHLBI | en_GB |
dc.description.sponsorship | Wellcome Trust | en_GB |
dc.description.sponsorship | Dutch Medical Research Foundation | en_GB |
dc.description.sponsorship | Spanish Government of Investigation, Development and Innovation | en_GB |
dc.description.sponsorship | NIDDK | en_GB |
dc.description.sponsorship | University of Manchester Research Infrastructure Fund | en_GB |
dc.description.sponsorship | ME | en_GB |
dc.description.sponsorship | National Institute for Health (NIH) | en_GB |
dc.identifier.citation | Vol. 10, article 1100 | en_GB |
dc.identifier.doi | 10.1038/s41467-019-08917-4 | |
dc.identifier.grantnumber | K01-HL135405-01 | en_GB |
dc.identifier.grantnumber | R01-HL113338-04 | en_GB |
dc.identifier.grantnumber | R35-HL135818-01 | en_GB |
dc.identifier.grantnumber | Unrestricted Grant (Sleep) | en_GB |
dc.identifier.grantnumber | N01‐HC‐25195 | en_GB |
dc.identifier.grantnumber | N02‐HL‐6‐4278 | en_GB |
dc.identifier.grantnumber | U01HL53941 | en_GB |
dc.identifier.grantnumber | 107849/Z/15/Z | en_GB |
dc.identifier.grantnumber | 016.VICI.170.200 | en_GB |
dc.identifier.grantnumber | VIDI 017.106.370 | en_GB |
dc.identifier.grantnumber | F32DK102323 | en_GB |
dc.identifier.grantnumber | 4T32HL007901 | en_GB |
dc.identifier.grantnumber | SAF2017- 84135-R | en_GB |
dc.identifier.grantnumber | R01DK105072 | en_GB |
dc.identifier.grantnumber | WT097835MF | en_GB |
dc.identifier.grantnumber | MR/M005070/1 | en_GB |
dc.identifier.grantnumber | MH108908 | en_GB |
dc.identifier.grantnumber | HL135818 | en_GB |
dc.identifier.grantnumber | 104150/Z/14/Z | en_GB |
dc.identifier.grantnumber | R01DK107859 | en_GB |
dc.identifier.grantnumber | DK102696 | en_GB |
dc.identifier.grantnumber | R35-HL135818 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/36477 | |
dc.language.iso | en | en_GB |
dc.publisher | Nature Research | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/30846698 | en_GB |
dc.rights | © The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/. | en_GB |
dc.title | Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates. | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2019-03-15T09:33:39Z | |
dc.identifier.issn | 2041-1723 | |
exeter.place-of-publication | England | en_GB |
dc.description | This is the author accepted manuscript. The final version is available from Nature Research via the DOI in this record. | en_GB |
dc.description | This research has been conducted using the UK Biobank Resource (UK Biobank application number 6818 and 9072) | en_GB |
dc.identifier.journal | Nature Communications | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2019-01-31 | |
rioxxterms.funder | European Research Council | en_GB |
rioxxterms.identifier.project | 323195:SZ-245 50371-GLUCOSEGENES-FP7-IDEAS-ERC | en_GB |
rioxxterms.version | AM | en_GB |
rioxxterms.licenseref.startdate | 2019-01-31 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2019-03-15T09:23:47Z | |
refterms.versionFCD | AM | |
refterms.dateFOA | 2019-03-15T09:33:43Z | |
refterms.panel | A | en_GB |
refterms.depositException | publishedGoldOA | |
rioxxterms.funder.project | cfc4e68f-b735-4d61-af14-d6be8d87e562 | en_GB |
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