Whispering-gallery mode (WGM) sensors: review of established and WGM-based techniques to study protein conformational dynamics
dc.contributor.author | Frustaci, S | |
dc.contributor.author | Vollmer, F | |
dc.date.accessioned | 2019-07-11T08:18:48Z | |
dc.date.issued | 2019-06-13 | |
dc.description.abstract | Monitoring the conformational dynamics of proteins is crucial for a better understanding of their biological functions. To observe the structural dynamics of proteins, it is often necessary to study each molecule individually. To this end, single-molecule techniques have been developed such as Förster resonance energy transfer and optical tweezers. However, although powerful, these techniques do have their limitations, for example, limited temporal resolution, or necessity for fluorescent labelling, and they can often only access a limited set of all protein motions. Here, within the context of established structural biology techniques, we review a new class of highly sensitive optical devices based on WGM, which characterise protein dynamics on previously inaccessible timescales, visualise motions throughout a protein, and track movements of single atoms. | en_GB |
dc.description.sponsorship | Engineering and Physical Sciences Research Council (EPSRC) | en_GB |
dc.identifier.citation | Vol. 51, pp. 66 - 73 | en_GB |
dc.identifier.doi | 10.1016/j.cbpa.2019.05.003 | |
dc.identifier.uri | http://hdl.handle.net/10871/37942 | |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier | en_GB |
dc.rights | © 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons. org/licenses/by/4.0/). | en_GB |
dc.title | Whispering-gallery mode (WGM) sensors: review of established and WGM-based techniques to study protein conformational dynamics | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2019-07-11T08:18:48Z | |
dc.identifier.issn | 1367-5931 | |
dc.description | This is the final version. Available on open access from Elsevier via the DOI in this record | en_GB |
dc.identifier.journal | Current Opinion in Chemical Biology | en_GB |
dc.rights.uri | http://creativecommons. org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2019-05-03 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2019-06-13 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2019-07-11T08:14:35Z | |
refterms.versionFCD | AM | |
refterms.dateFOA | 2019-07-31T11:57:08Z | |
refterms.panel | B | en_GB |
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open access article under the CC BY license (http://creativecommons.
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