dc.contributor.author | White, RR | |
dc.contributor.author | Lin, C | |
dc.contributor.author | Leaves, I | |
dc.contributor.author | Castro, I | |
dc.contributor.author | Metz, J | |
dc.contributor.author | Bateman, B | |
dc.contributor.author | Botchway, S | |
dc.contributor.author | Ward, A | |
dc.contributor.author | Ashwin, P | |
dc.contributor.author | Sparkes, I | |
dc.date.accessioned | 2020-02-26T09:58:04Z | |
dc.date.issued | 2020-04-03 | |
dc.description.abstract | Mitochondria are essential for energy conversion, and metabolic pathways including
photorespiration, biosynthesis of coenzymes and vitamins. They are highly pleomorphic
undergoing rounds of fission and fusion through processes coupled with the metabolic status
of the cell. For example, fusion favours higher energy demand and, unlike fission, the
molecular components involved in mitochondrial fusion in plants are unknown. Here, we show
a role for the GTPase Miro2 in mitochondria interaction with the ER and its impacts on
mitochondria fusion and motility. Interaction between these two organelles has been inferred
from close positioning. Mutations in AtMiro2’s GTPase domain indicate that the active variant
results in larger, fewer mitochondria which are attached more readily to the ER when compared
with the inactive variant. These results are contrary to those in metazoans where Miro
predominantly controls mitochondrial motility with additional GTPases affecting fusion.
Synthetically controlling mitochondrial fusion rates could fundamentally change plant
physiology by altering the energy status of the cell. Furthermore, altering tethering to the ER
could have profound effects on subcellular communication through altering the exchange
required for pathogen defence. | en_GB |
dc.description.sponsorship | Leverhulme Trust | en_GB |
dc.description.sponsorship | Science and Technology Facilities Council (STFC) | en_GB |
dc.identifier.citation | Vol. 3 (161). Published online 03 April 2020. | en_GB |
dc.identifier.doi | 10.1038/s42003-020-0872-x | |
dc.identifier.grantnumber | RPG-2015-106 | en_GB |
dc.identifier.grantnumber | PM-1216 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/40991 | |
dc.language.iso | en | en_GB |
dc.publisher | Nature Research | en_GB |
dc.rights | © The Author(s) 2020. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | |
dc.subject | mitochondria | en_GB |
dc.subject | ER | en_GB |
dc.subject | Miro | en_GB |
dc.subject | plant | en_GB |
dc.subject | tethering | en_GB |
dc.title | Miro2 tethers the ER to mitochondria to promote mitochondrial fusion in tobacco leaf epidermal cells | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2020-02-26T09:58:04Z | |
dc.identifier.issn | 2399-3642 | |
dc.description | This is the final version. Available from Nature Research via the DOI in this record. | en_GB |
dc.description | Data availability:
All data generated or analysed during this study are included in this published article (and its
supplementary information files). | en_GB |
dc.identifier.journal | Communications Biology | en_GB |
dc.rights.uri | http://www.rioxx.net/licenses/all-rights-reserved | en_GB |
dcterms.dateAccepted | 2020-02-25 | |
exeter.funder | ::Leverhulme Trust | en_GB |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2020-02-25 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2020-02-25T19:35:30Z | |
refterms.versionFCD | AM | |
refterms.dateFOA | 2020-04-09T11:05:40Z | |
refterms.panel | B | en_GB |