Leukocyte CCR2 expression is associated with mini-mental state examination score in older adults
Harries, LW; Bradley-Smith, Rachel; Llewellyn, DJ; et al.Pilling, LC; Fellows, A; Henley, William E.; Hernandez, Dena; Guralnik, Jack; Bandinelli, S; Singleton, A; Ferrucci, L; Melzer, D
Date: 1 August 2012
Article
Journal
Rejuvenation Research
Publisher
Mary Ann Liebert
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Abstract
Circulating inflammatory markers may play an important role in cognitive impairment at older ages. Mice deficient for the chemokine (C-C motif) receptor 2 (CCR2) develop an accelerated Alzheimer-like pathology. CCR2 is also important in neurogenesis. To identify human gene transcripts most closely associated with Mini-Mental State ...
Circulating inflammatory markers may play an important role in cognitive impairment at older ages. Mice deficient for the chemokine (C-C motif) receptor 2 (CCR2) develop an accelerated Alzheimer-like pathology. CCR2 is also important in neurogenesis. To identify human gene transcripts most closely associated with Mini-Mental State Examination (MMSE) scores, we undertook a genome-wide and inflammation specific transcriptome screen in circulating leukocytes from a population-based sample.
Institute of Biomedical & Clinical Science
Collections of Former Colleges
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