The cytoplasmic dynein motor complex at microtubule plus-ends and in long range motility of early endosomes, microtubule plus-end anchorage and processivity of cytoplasmic dynein.
a copy of the full thesis (3.662Mb) 'front matter' (52.97Kb) Chapter 2.1. Movie S1_EE motility in dynein mutants (723.0Kb) Chapter 2.1. Movie S2_Dynein motility in Control, DTcTex and LC8 mutants_B (431.2Kb) Chapter 2.1. Movie S3_Dynein motility in DLIC and DLC2 mutants2 (11.05Mb) Chapter 2.1. Movie S4_Spindle elongation in dynein mutants (1.598Mb) Chapter 2.2. Movie S1_Anaphase in a control cell (543.0Kb) Chapter 2.2. Movie S2_Dynein at astral MTs (360.3Kb) Chapter 2.2. Movie S3_Off-loading of dynein in a control cell (1.576Mb) Chapter 2.2. Movie S4_Anaphase in Clip1 null mutants (943.8Kb) Chapter 2.2. Movie S5_Anaphase in Lis1,NudE, Lis1Clip1 and NudEClip1mutants (634.8Kb)Show MoreShow Less
Thesis or dissertation
University of Exeter
Reason for embargo
waiting for publishing
Showing items related by title, author, creator and subject.
Dagdas, Gulay (University of ExeterBiological Sciences, 2015-06-04)Peroxisomes are ubiquitous organelles found in almost all eukaryotes. They are sensitive to changes in cellular homeostasis and involved in various metabolic processes. Deficiencies in peroxisome function cause severe ...
Guimaraes, SC; Schuster, M; Bielska, E; Dagdas, G; Kilaru, S; Meadows, BR; Schrader, M; Steinberg, G (Rockefeller University Press, 2015-12-07)Intracellular transport is mediated by molecular motors that bind cargo to be transported along the cytoskeleton. Here, we report, for the first time, that peroxisomes (POs), lipid droplets (LDs), and the endoplasmic ...
Higuchi, Y; Ashwin, P; Roger, Y; Steinberg, G (Rockefeller University Press, 2014-02-03)Early endosomes (EEs) mediate protein sorting, and their cytoskeleton-dependent motility supports long-distance signaling in neurons. Here, we report an unexpected role of EE motility in distributing the translation machinery ...