Does Obesity Cause Thyroid Cancer? A Mendelian Randomization Study
dc.contributor.author | Fussey, JM | |
dc.contributor.author | Beaumont, RN | |
dc.contributor.author | Wood, AR | |
dc.contributor.author | Vaidya, B | |
dc.contributor.author | Smith, J | |
dc.contributor.author | Tyrrell, J | |
dc.date.accessioned | 2020-09-07T12:31:09Z | |
dc.date.issued | 2020-05-11 | |
dc.description.abstract | BACKGROUND: The incidence of thyroid cancer is rising, and relatively little is known about modifiable risk factors for the condition. Observational studies have suggested a link between adiposity and thyroid cancer; however, these are subject to confounding and reverse causality. Here, we used data from the UK Biobank and Mendelian randomization approaches to investigate whether adiposity causes benign nodular thyroid disease and differentiated thyroid cancer. METHODS: We analyzed data from 379 708 unrelated participants of European ancestry in the UK Biobank and identified 1812 participants with benign nodular thyroid disease and 425 with differentiated thyroid carcinoma. We tested observational associations with measures of adiposity and type 2 diabetes mellitus. One and 2-sample Mendelian randomization approaches were used to investigate causal relationships. RESULTS: Observationally, there were positive associations between higher body mass index (odds ratio [OR], 1.15; 95% confidence interval [CI], 1.08-1.22), higher waist-hip ratio (OR, 1.16; 95% CI, 1.09-1.23), and benign nodular thyroid disease, but not thyroid cancer. Mendelian randomization did not support a causal link for obesity with benign nodular thyroid disease or thyroid cancer, although it did provide some evidence that individuals in the highest quartile for genetic liability of type 2 diabetes had higher odds of thyroid cancer than those in the lowest quartile (OR, 1.45; CI, 1.11-1.90). CONCLUSIONS: Contrary to the findings of observational studies, our results do not confirm a causal role for obesity in benign nodular thyroid disease or thyroid cancer. They do, however, suggest a link between type 2 diabetes and thyroid cancer. | en_GB |
dc.description.sponsorship | UK Biobank | en_GB |
dc.description.sponsorship | Academy of Medical Sciences (AMS) | en_GB |
dc.description.sponsorship | Wellcome Trust | en_GB |
dc.description.sponsorship | GCRF | en_GB |
dc.description.sponsorship | the Government Department of Business, Energy and Industrial strategy, | en_GB |
dc.description.sponsorship | British Heart Foundation | en_GB |
dc.description.sponsorship | Diabetes UK | en_GB |
dc.description.sponsorship | Royal Society | en_GB |
dc.identifier.citation | Vol. 105 (7) pp. e2398–e2407 | en_GB |
dc.identifier.doi | 10.1210/clinem/dgaa250 | |
dc.identifier.grantnumber | 9072 | en_GB |
dc.identifier.grantnumber | SBF004\1079 | en_GB |
dc.identifier.grantnumber | WT104150 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/122747 | |
dc.language.iso | en | en_GB |
dc.publisher | Endocrine Society / Oxford University Press | en_GB |
dc.rights | © Endocrine Society 2020. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. | en_GB |
dc.subject | molecular epidemiology | en_GB |
dc.subject | mendelian randomization | en_GB |
dc.subject | thyroid neoplasms | en_GB |
dc.subject | obesity | en_GB |
dc.subject | diabetes mellitus | en_GB |
dc.subject | type 2 | en_GB |
dc.title | Does Obesity Cause Thyroid Cancer? A Mendelian Randomization Study | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2020-09-07T12:31:09Z | |
dc.identifier.issn | 0021-972X | |
dc.description | This is the final version. Available from Endocrine Society / Oxford University Press via the DOI in this record. | en_GB |
dc.identifier.journal | The Journal of clinical endocrinology and metabolism | en_GB |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2020-05-05 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2020-05-05 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2020-09-07T12:26:02Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2020-09-07T12:31:14Z | |
refterms.panel | A | en_GB |
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Except where otherwise noted, this item's licence is described as © Endocrine Society 2020. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.