Brain-body control of glucose homeostasis - insights from model organisms
dc.contributor.author | MacDonald, AJ | |
dc.contributor.author | Yang, YHC | |
dc.contributor.author | Cruz, AM | |
dc.contributor.author | Beall, C | |
dc.contributor.author | Ellacott, KLJ | |
dc.date.accessioned | 2021-07-14T12:30:18Z | |
dc.date.issued | 2021-03-31 | |
dc.description.abstract | Tight regulation of blood glucose is essential for long term health. Blood glucose levels are defended by the correct function of, and communication between, internal organs including the gastrointestinal tract, pancreas, liver, and brain. Critically, the brain is sensitive to acute changes in blood glucose level and can modulate peripheral processes to defend against these deviations. In this mini-review we highlight select key findings showcasing the utility, strengths, and limitations of model organisms to study brain-body interactions that sense and control blood glucose levels. First, we discuss the large platform of genetic tools available to investigators studying mice and how this field may yet reveal new modes of communication between peripheral organs and the brain. Second, we discuss how rats, by virtue of their size, have unique advantages for the study of CNS control of glucose homeostasis and note that they may more closely model some aspects of human (patho)physiology. Third, we discuss the nascent field of studying the CNS control of blood glucose in the zebrafish which permits ease of genetic modification, large-scale measurements of neural activity and live imaging in addition to high-throughput screening. Finally, we briefly discuss glucose homeostasis in drosophila, which have a distinct physiology and glucoregulatory systems to vertebrates. | en_GB |
dc.description.sponsorship | Diabetes UK | en_GB |
dc.description.sponsorship | Juvenile Diabetes Research Foundation | en_GB |
dc.description.sponsorship | Expanding Excellence in England | en_GB |
dc.identifier.citation | Vol. 12, article 662769 | en_GB |
dc.identifier.doi | 10.3389/fendo.2021.662769 | |
dc.identifier.grantnumber | 19/ 0006035 | en_GB |
dc.identifier.grantnumber | 1-INO-2020-919-A-N | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/126407 | |
dc.language.iso | en | en_GB |
dc.publisher | Frontiers Media | en_GB |
dc.rights | © 2021 MacDonald, Yang, Cruz, Beall and Ellacott. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | en_GB |
dc.subject | brain | en_GB |
dc.subject | glucose homeostasis | en_GB |
dc.subject | model organism | en_GB |
dc.subject | mouse | en_GB |
dc.subject | rat | en_GB |
dc.subject | zebrafish | en_GB |
dc.title | Brain-body control of glucose homeostasis - insights from model organisms | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2021-07-14T12:30:18Z | |
dc.identifier.issn | 1664-2392 | |
dc.description | This is the final version. Available on open access from Frontiers Media via the DOI in this record. | en_GB |
dc.identifier.journal | Frontiers in Endocrinology | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2021-03-12 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2021-03-31 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2021-07-14T12:27:29Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2021-07-14T12:30:36Z | |
refterms.panel | A | en_GB |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's licence is described as © 2021 MacDonald, Yang, Cruz, Beall and Ellacott. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.