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dc.contributor.authorMacDonald, AJ
dc.contributor.authorYang, YHC
dc.contributor.authorCruz, AM
dc.contributor.authorBeall, C
dc.contributor.authorEllacott, KLJ
dc.date.accessioned2021-07-14T12:30:18Z
dc.date.issued2021-03-31
dc.description.abstractTight regulation of blood glucose is essential for long term health. Blood glucose levels are defended by the correct function of, and communication between, internal organs including the gastrointestinal tract, pancreas, liver, and brain. Critically, the brain is sensitive to acute changes in blood glucose level and can modulate peripheral processes to defend against these deviations. In this mini-review we highlight select key findings showcasing the utility, strengths, and limitations of model organisms to study brain-body interactions that sense and control blood glucose levels. First, we discuss the large platform of genetic tools available to investigators studying mice and how this field may yet reveal new modes of communication between peripheral organs and the brain. Second, we discuss how rats, by virtue of their size, have unique advantages for the study of CNS control of glucose homeostasis and note that they may more closely model some aspects of human (patho)physiology. Third, we discuss the nascent field of studying the CNS control of blood glucose in the zebrafish which permits ease of genetic modification, large-scale measurements of neural activity and live imaging in addition to high-throughput screening. Finally, we briefly discuss glucose homeostasis in drosophila, which have a distinct physiology and glucoregulatory systems to vertebrates.en_GB
dc.description.sponsorshipDiabetes UKen_GB
dc.description.sponsorshipJuvenile Diabetes Research Foundationen_GB
dc.description.sponsorshipExpanding Excellence in Englanden_GB
dc.identifier.citationVol. 12, article 662769en_GB
dc.identifier.doi10.3389/fendo.2021.662769
dc.identifier.grantnumber19/ 0006035en_GB
dc.identifier.grantnumber1-INO-2020-919-A-Nen_GB
dc.identifier.urihttp://hdl.handle.net/10871/126407
dc.language.isoenen_GB
dc.publisherFrontiers Mediaen_GB
dc.rights© 2021 MacDonald, Yang, Cruz, Beall and Ellacott. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_GB
dc.subjectbrainen_GB
dc.subjectglucose homeostasisen_GB
dc.subjectmodel organismen_GB
dc.subjectmouseen_GB
dc.subjectraten_GB
dc.subjectzebrafishen_GB
dc.titleBrain-body control of glucose homeostasis - insights from model organismsen_GB
dc.typeArticleen_GB
dc.date.available2021-07-14T12:30:18Z
dc.identifier.issn1664-2392
dc.descriptionThis is the final version. Available on open access from Frontiers Media via the DOI in this record. en_GB
dc.identifier.journalFrontiers in Endocrinologyen_GB
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_GB
dcterms.dateAccepted2021-03-12
rioxxterms.versionVoRen_GB
rioxxterms.licenseref.startdate2021-03-31
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2021-07-14T12:27:29Z
refterms.versionFCDVoR
refterms.dateFOA2021-07-14T12:30:36Z
refterms.panelAen_GB


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© 2021 MacDonald, Yang, Cruz, Beall and Ellacott. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Except where otherwise noted, this item's licence is described as © 2021 MacDonald, Yang, Cruz, Beall and Ellacott. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.