Clinical and Biomedical Sciences: Recent submissions
Now showing items 36-40 of 330
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Detecting and monitoring incontinence associated dermatitis: Does impedance spectroscopy have a part to play?
(SAGE Publications, 1 June 2024)In this review, current understanding of the prevention and treatment of Incontinence Associated Dermatitis (IAD) is discussed. The need for preventative measures which target specific faecal/urinary irritants is highlighted, ... -
Nitric oxide releasing nanomaterials for cardiovascular applications.
(Elsevier, 27 May 2024)A central paradigm of cardiovascular homeostasis is that impaired nitric oxide (NO) bioavailability results in a wide array of cardiovascular dysfunction including incompetent endothelium-dependent vasodilatation, thrombosis, ... -
Congenital hyperinsulinism and novel KDM6A duplications - resolving pathogenicity with genome and epigenetic analyses
(Oxford University Press / The Endocrine Society, 30 July 2024)CONTEXT: Hyperinsulinemic hypoglycemia (HI) can be the presenting feature of Kabuki syndrome (KS), which is caused by loss-of-function variants in KMT2D or KDM6A. As these genes play a critical role in maintaining methylation ... -
An evaluation of the replacement of animal-derived biomaterials in human primary cell culture
(SAGE Publications, 9 August 2024)The likelihood that potential new drugs will successfully navigate the current translational pipeline is poor, with fewer than 10% of drug candidates making this transition successfully, even after their entry into clinical ... -
Coxsackievirus infection induces direct pancreatic β cell killing but poor antiviral CD8+ T cell responses.
(American Association for the Advancement of Science, 6 March 2024)Coxsackievirus B (CVB) infection of pancreatic β cells is associated with β cell autoimmunity and type 1 diabetes. We investigated how CVB affects human β cells and anti-CVB T cell responses. β cells were efficiently ...