Gallstone pancreatitis vs alcohol-induced pancreatitis: does aetiology affect the extent of pancreatic necrosis?
dc.contributor.author | Di Mauro, D | |
dc.contributor.author | Alexiadis, A | |
dc.contributor.author | Njere, I | |
dc.contributor.author | Shams, O | |
dc.contributor.author | Reece-Smith, A | |
dc.contributor.author | Wajed, S | |
dc.contributor.author | Osman, NA | |
dc.contributor.author | Manzelli, A | |
dc.date.accessioned | 2024-04-25T14:19:10Z | |
dc.date.issued | 2024-04-24 | |
dc.date.updated | 2024-04-25T13:51:47Z | |
dc.description.abstract | Background and aim: The impact of different aetiologies of acute pancreatitis on the development of pancreatic necrosis (PN) is unclear. This study assessed the extent and progression of pancreatic and peripan-creatic necrosis on the computed tomography (CT) scan of patients with gallstone (GP) and alcohol-induced (AIP) pancreatitis and evaluated their impact on disease severity. Methods: Patients ≥ 18-year-old with GP, AIP and PN on CT ( January 2010 – September 2018), were considered. The radiological extent of PN and clinical outcomes were analysed with a logistic regression model. Results: Eighty-one patients, 59 with GP, 22 with AIP, were included. GP had a larger extent of PN when the body and/or tail of the pancreas were involved (P = 0.009). Gallstone disease (P = 0.028) and higher American Society of Anesthetists scores (P = 0.043) were predictors of necrosis diffuse to different areas of the pancreas. Predictors of single/multiple organ failure were GP (P = 0.040), necrosis > 50% of the pancreas (P = 0.002) with a diffuse pattern (P = 0.004). Conclusions: Patients with GP had a wider extent of necrosis in the pancreatic body and/or tail. The onset of organ failure can be predicted in subjects with GP and larger amount of PN. | en_GB |
dc.identifier.citation | Vol. 95 (2), article e2024023 | en_GB |
dc.identifier.doi | https://doi.org/10.23750/abm.v95i2.15416 | |
dc.identifier.uri | http://hdl.handle.net/10871/135818 | |
dc.identifier | ORCID: 0000-0003-2348-5664 (Di Mauro, Davide) | |
dc.language.iso | en | en_GB |
dc.publisher | Mattioli 1885 | en_GB |
dc.rights | © 2023 Davide Di Mauro, Aris Alexiadis, Ikechukwu Njere, Ola Shams, Alex Reece-Smith, Shahjehan Wajed, Nermin Ahmed Osman, Antonio Manzelli. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | en_GB |
dc.subject | Acute pancreatitis | en_GB |
dc.subject | Pancreatic necrosis | en_GB |
dc.subject | Alcoholic pancreatitis | en_GB |
dc.subject | Gallstones | en_GB |
dc.title | Gallstone pancreatitis vs alcohol-induced pancreatitis: does aetiology affect the extent of pancreatic necrosis? | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2024-04-25T14:19:10Z | |
dc.identifier.issn | 0392-4203 | |
dc.description | This is the final version. Available on open access from Mattioli 1885 via the DOI in this record | en_GB |
dc.identifier.eissn | 2531-6745 | |
dc.identifier.journal | Acta Biomedica | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | en_GB |
dcterms.dateAccepted | 2023-11-20 | |
dcterms.dateSubmitted | 2023-11-16 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2024-04-24 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2024-04-25T14:16:39Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2024-04-25T14:19:21Z | |
refterms.panel | A | en_GB |
refterms.dateFirstOnline | 2024-04-24 |
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Except where otherwise noted, this item's licence is described as © 2023 Davide Di Mauro, Aris Alexiadis, Ikechukwu Njere, Ola Shams, Alex Reece-Smith, Shahjehan Wajed, Nermin Ahmed Osman, Antonio Manzelli. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.