Show simple item record

dc.contributor.authorVoliotis, M
dc.contributor.authorGarner, KL
dc.contributor.authorAlobaid, H
dc.contributor.authorTsaneva-Atanasova, K
dc.contributor.authorMcArdle, CA
dc.date.accessioned2017-08-14T12:31:21Z
dc.date.issued2017-07-29
dc.description.abstractGonadotropin-releasing hormone (GnRH) is a peptide hormone that mediates central control of reproduction, acting via G-protein coupled receptors that are primarily Gq coupled and mediate GnRH effects on the synthesis and secretion of luteinizing hormone and follicle-stimulating hormone. A great deal is known about the GnRH receptor signaling network but GnRH is secreted in short pulses and much less is known about how gonadotropes decode this pulsatile signal. Similarly, single cell measures reveal considerable cell-cell heterogeneity in responses to GnRH but the impact of this variability on signaling is largely unknown. Ordinary differential equation-based mathematical models have been used to explore the decoding of pulse dynamics and information theory-derived statistical measures are increasingly used to address the influence of cell-cell variability on the amount of information transferred by signaling pathways. Here, we describe both approaches for GnRH signaling, with emphasis on novel insights gained from the information theoretic approach and on the fundamental question of why GnRH is secreted in pulses.en_GB
dc.description.sponsorshipThis work was funded Project Grants from MRC (93447) and the BBSRC (J014699). KTA and MV gratefully acknowledge the financial support of the EPSRC via grant EP/N014391/1 and an MRC Biomedical Informatics Fellowship (MR/K021826/1), respectively.en_GB
dc.identifier.citationAvailable online 29 July 2017en_GB
dc.identifier.doi10.1016/j.mce.2017.07.028
dc.identifier.urihttp://hdl.handle.net/10871/28899
dc.language.isoenen_GB
dc.publisherElsevieren_GB
dc.rights.embargoreasonPublisher's policy.en_GB
dc.rights© 2017 Published by Elsevier Ireland Ltd.en_GB
dc.subjectGnRHen_GB
dc.subjectGPCRen_GB
dc.subjectNFATen_GB
dc.subjectERKen_GB
dc.subjectMathematical modelingen_GB
dc.subjectMutual informationen_GB
dc.titleGonadotropin-releasing hormone signaling: An information theoretic approachen_GB
dc.typeArticleen_GB
dc.identifier.issn0303-7207
dc.descriptionThis is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record.en_GB
dc.identifier.journalMolecular and Cellular Endocrinologyen_GB


Files in this item

This item appears in the following Collection(s)

Show simple item record