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Epigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerative diseases

dc.contributor.authorRoubroeks, JAY
dc.contributor.authorSmith, RG
dc.contributor.authorvan den Hove, DLA
dc.contributor.authorLunnon, K
dc.date.accessioned2018-06-14T15:56:45Z
dc.date.issued2017-08-14
dc.description.abstractRecent studies have suggested a role for epigenetic mechanisms in the complex etiology of various neurodegenerative diseases. In this review, we discuss advances that have been made toward understanding the role of epigenetic processes in neurodegenerative disorders, with a particular focus on Alzheimer's disease, where the most extensive studies have been undertaken to date. We provide a brief overview of DNA modifications, followed by a summarization of studies of DNA modifications in Alzheimer's disease and other neurodegenerative diseases.en_GB
dc.identifier.citationVol. 143, pp. 158 - 170en_GB
dc.identifier.doi10.1111/jnc.14148
dc.identifier.urihttp://hdl.handle.net/10871/33207
dc.language.isoenen_GB
dc.publisherWileyen_GB
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pubmed/28805248en_GB
dc.rights.embargoreasonUnder embargo until 14 August 2018 in compliance with publisher policy.en_GB
dc.rightsThis work was funded by an Alzheimer’s Society project grant to KL (grant number AS-PG-14-038) and an Alzheimer’s Association New Investigator Research Grant to KL (grant number NIRG-14-320878). Janou Roubroeks is supported by the GW4 Biomed MRC Doctoral Training Partnerships.en_GB
dc.subjectAlzheimer's diseaseen_GB
dc.subjectDNA hydroxymethylationen_GB
dc.subjectDNA methylationen_GB
dc.subjectepigeneticen_GB
dc.subjectepigenome-wide association studyen_GB
dc.subjectgeneticen_GB
dc.subjectAlzheimer Diseaseen_GB
dc.subjectAnimalsen_GB
dc.subjectDNA Methylationen_GB
dc.subjectEpigenesis, Geneticen_GB
dc.subjectGene Expression Profilingen_GB
dc.subjectHumansen_GB
dc.subjectNeurodegenerative Diseasesen_GB
dc.titleEpigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerative diseasesen_GB
dc.typeArticleen_GB
dc.identifier.issn0022-3042
exeter.place-of-publicationEnglanden_GB
dc.descriptionThis is the author accepted manuscript. The final version is available from the publisher via the DOI in this recorden_GB
dc.identifier.journalJournal of Neurochemistryen_GB


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