Co-evolutionary and systemic study on the evolution of emerging stem cell-based therapies
Ávila-Robinsona, A; Islam, N; Sengoku, S
Date: 23 October 2018
Journal
Technological Forecasting and Social Change
Publisher
Elsevier
Publisher DOI
Abstract
Newly emerging therapeutic technologies have the potential to reconfigure the understanding, diagnosis, and
treatment of diseases, and, consequently, to impact human health. This study integrates co-evolutionary and
system-oriented perspectives to investigate factors influencing the way emerging therapies evolve in their attempt
to ...
Newly emerging therapeutic technologies have the potential to reconfigure the understanding, diagnosis, and
treatment of diseases, and, consequently, to impact human health. This study integrates co-evolutionary and
system-oriented perspectives to investigate factors influencing the way emerging therapies evolve in their attempt
to become established medical practices. We examined the case of the use of induced pluripotent stem (iPS) cellbased
therapies for age-related macular degeneration (AMD) disease. Cell therapy evolution is explored by
considering their constitutive components, namely disease, biomedical technologies, and clinical practices, and
observing the changes experienced by their underlying knowledge structures. We adopted a mixed methods
approach that simultaneously uses publication, patent, and clinical trial data. Our results highlight the significance
of the diversity of technological possibilities, the role of subjective issues in the selection of directions of search,
the complementary nature between established and emerging therapies, and the tight product-process
interdependencies. This study contributes to an understanding of the difficulties encountered during the emergence
of new cell therapies, and the ways in which such difficulties can be circumvented to establish effective and safe
cell-based clinical practices.
Management
Faculty of Environment, Science and Economy
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