dc.contributor.author | Ávila-Robinsona, A | |
dc.contributor.author | Islam, N | |
dc.contributor.author | Sengoku, S | |
dc.date.accessioned | 2018-10-16T10:00:08Z | |
dc.date.issued | 2018-10-23 | |
dc.description.abstract | Newly emerging therapeutic technologies have the potential to reconfigure the understanding, diagnosis, and
treatment of diseases, and, consequently, to impact human health. This study integrates co-evolutionary and
system-oriented perspectives to investigate factors influencing the way emerging therapies evolve in their attempt
to become established medical practices. We examined the case of the use of induced pluripotent stem (iPS) cellbased
therapies for age-related macular degeneration (AMD) disease. Cell therapy evolution is explored by
considering their constitutive components, namely disease, biomedical technologies, and clinical practices, and
observing the changes experienced by their underlying knowledge structures. We adopted a mixed methods
approach that simultaneously uses publication, patent, and clinical trial data. Our results highlight the significance
of the diversity of technological possibilities, the role of subjective issues in the selection of directions of search,
the complementary nature between established and emerging therapies, and the tight product-process
interdependencies. This study contributes to an understanding of the difficulties encountered during the emergence
of new cell therapies, and the ways in which such difficulties can be circumvented to establish effective and safe
cell-based clinical practices. | en_GB |
dc.description.sponsorship | This work was financially
supported by MEXT/JSPS World Premier International Research Center (WPI) Initiative [AAR] and by
MEXT/JSPS Kakenhi Grant No. 26301022 [SS] and MEXT/JSPS Kakenhi Grant No. 16K17165 [AAR].
Funding is also provided by Organisation in Transition Research Cluster, University of Exeter Business School,
University of Exeter, UK (No. 1-SC-C-N68-242-USC01-SSC31-A355-PZSC177). | en_GB |
dc.identifier.citation | Published online 23 October 2018. | en_GB |
dc.identifier.doi | 10.1016/j.techfore.2018.10.012 | |
dc.identifier.uri | http://hdl.handle.net/10871/34309 | |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier | en_GB |
dc.rights.embargoreason | Under embargo until 21 April 2020 in compliance with publisher policy. | en_GB |
dc.rights | © 2018 Elsevier Inc. All rights reserved. | |
dc.title | Co-evolutionary and systemic study on the evolution of emerging stem cell-based therapies | en_GB |
dc.type | Article | en_GB |
dc.identifier.issn | 0040-1625 | |
dc.description | This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record. | en_GB |
dc.identifier.journal | Technological Forecasting and Social Change | en_GB |